{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T04:04:10Z","timestamp":1779595450505,"version":"3.53.1"},"reference-count":98,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2026,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Newborns with gastroschisis hospitalised in the neonatal intensive care unit (NICU) are at risk for a disrupted gut microbiome. Infants with gastroschisis are particularly vulnerable to a dysbiotic microbiome; they require prolonged parenteral nutrition (PN) due to intestinal dysmotility, which often leads to growth faltering (GF). This pilot study\u2019s goals were to (1) compare the gut microbiome in infants with gastroschisis to infants admitted to the NICU without congenital anomalies, (2) identify differences in the gut microbiome between infants with gastroschisis requiring prolonged PN and those who do not, and (3) compare the microbiome in infants with gastroschisis with GF to those without GF. This was a multi-site prospective cohort study including 17 infants born with gastroschisis and 16 infants with a gestational age greater than 34 weeks admitted to the NICU without congenital anomalies (controls). Prolonged PN was defined as more than 28 days. GF was defined as a decline in weight or length z-score from birth to discharge of \u2264-0.8. Stool samples were collected weekly during hospitalisation and analysed by shotgun metagenomics to assess bacterial composition, diversity, and function. Gestational age and birth weight were similar in the gastroschisis group and the control group. Infants with gastroschisis showed increased\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and decreased\n                    <jats:italic>Bifidobacterium longum<\/jats:italic>\n                    . Those requiring prolonged PN had a reduced abundance of genes in the glucosidase pathway compared to those who did not. Infants with GF showed a lower abundance of genes involved in the NAD-diphosphatase pathway compared to those without GF. Infants with gastroschisis display a distinct microbial composition and function compared to NICU infants without this condition. Among infants with gastroschisis, differences in bacterial functional capacity were observed in those who required prolonged PN and developed GF.\n                  <\/jats:p>","DOI":"10.1163\/18762891-bja00121","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T03:04:09Z","timestamp":1779591849000},"page":"1-14","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbial differences and function in infants with gastroschisis: a pilot prospective cohort study"],"prefix":"10.1163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-0425","authenticated-orcid":true,"given":"K.M.","family":"Strobel","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, https:\/\/dx.doi.org\/7284University of Washington, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Leibel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of California, San Diego, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bhute","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Goodman-Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Aja","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Goodman-Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Goodman-Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Calkins","sequence":"additional","affiliation":[{"name":"Goodman-Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"R000001","series-title":"Obstetrics and Gynaecology","first-page":"163","article-title":"A United States national reference for fetal growth","volume":"87","author":"Alexander, G.R.","unstructured":"Alexander, G.R., Himes, J.H., Kaufman, R.B., Mor, J. and Kogan, M., 1996. 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