{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:46:28Z","timestamp":1782531988169,"version":"3.54.5"},"reference-count":120,"publisher":"Walter de Gruyter GmbH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Benef. Microbes"],"published-print":{"date-parts":[[2026,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The multi-strain probiotic formulation (MPF \u2013 Oxxyslab\u2122) regulates several biological processes, including oxygenation in human and mouse models of neurodegenerative diseases. Its effect on oxidative metabolism of tumour cells has not yet been investigated. Employing a polarographic approach, we examined the effect of a lysate of MPF and its constituent strains on oxidative phosphorylation (OXPHOS) in colorectal cancer cells. Results indicate that MPF lysate selectively inhibits OXPHOS in undifferentiated but not in differentiated Caco-2 cells. Ceramides, produced through bacterial sphingomyelinase activity, mediate the inhibitory effects of MPF lysate, and the efficacy of the lysate of individual MPF strains in blocking cellular respiration varies due to strain-specific differences in ceramide production. Our results demonstrate that MPF lysate exhibits anti-OXPHOS activity in human colorectal carcinoma cells, selectively targeting undifferentiated Caco-2 cells but not differentiated ones. The reliance of colorectal cancer cells on OXPHOS provides a scientific basis for exploring MPF probiotic formulation as a complementary approach to conventional pharmacology.<\/jats:p>","DOI":"10.1163\/18762891-bja00124","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:04:35Z","timestamp":1782529475000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["A lysate of a multi-strain probiotic formulation inhibits cell growth and oxidative phosphorylation in colorectal cancer cells via a ceramide-mediated mechanism"],"prefix":"10.1163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-4906","authenticated-orcid":true,"given":"D.","family":"Gnocchi","sequence":"first","affiliation":[{"name":"Interdisciplinary Department of Medicine, https:\/\/dx.doi.org\/579980University of Bari Aldo Moro School of Medicine, Piazza G. Cesare 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-5076","authenticated-orcid":true,"given":"F.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-9416","authenticated-orcid":true,"given":"B.","family":"Cinque","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-8151","authenticated-orcid":true,"given":"R.R.","family":"Paparella","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine, https:\/\/dx.doi.org\/579980University of Bari Aldo Moro School of Medicine, Piazza G. 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