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The transcriptional regulatory factor nuclear factor-\u03baB (NF-\u03baB) is involved in modulating the expression of many cytokines and other proinflammatory mediators implicated in the development and progression of ALI. Because neutrophils appear to play a major role in the development of ALI, we examined the relationships between clinical outcome and activation of NF-\u03baB in peripheral neutrophils from patients (n = 30) with sepsis-induced ALI. We found that nuclear translocation of NF-\u03baB in this setting was dependent on the activation of p38 and Akt kinases. Diminished activation of NF-\u03baB or Akt, but not p38, in the early postintubation period was associated with less time on the ventilator and improved survival in critically ill patients with ALI. These results suggest that early alterations in neutrophil activation patterns, particularly involving the ability to accumulate NF-\u03baB to the nucleus after relevant stimuli, contribute to subsequent clinical course in ALI.<\/jats:p>","DOI":"10.1164\/rccm.200207-664oc","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T20:50:20Z","timestamp":1047329420000},"page":"1567-1574","source":"Crossref","is-referenced-by-count":103,"title":["Early Alterations in Neutrophil Activation Are Associated with Outcome in Acute Lung Injury"],"prefix":"10.1093","volume":"167","author":[{"given":"Kuang-Yao","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Science Center, Denver, Colorado; Chest Department, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, 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