{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:21:39Z","timestamp":1774567299411,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The study was designed to assess the effect of cigarette smoking on the therapeutic response to oral corticosteroids in chronic stable asthma. We performed a randomized, placebo-controlled, crossover study with prednisolone (40 mg daily) or placebo for 2 weeks in smokers with asthma, ex-smokers with asthma, and never-smokers with asthma. All subjects had reversibility in FEV1 after nebulized albuterol of 15% or more and a mean postbronchodilator FEV1% predicted of more than 80%. Efficacy was assessed using FEV1, daily PEF, and an asthma control score. There was a significant improvement after oral prednisolone compared with placebo in FEV1, ml (mean difference, 237; 95% confidence intervals, 43, 231; p = 0.019), morning PEF L\/m (mean difference, 36.8; 95% confidence intervals (CI), 11, 62; p = 0.006), and asthma control score (mean difference, \u22120.72; 95% CI, \u22121.2, \u22120.3; p = 0.004) in never-smokers with asthma but no change in smokers with asthma (mean differences of 47, 6.5, and \u22120.05 with p values of 0.605, 0.47, and 0.865, respectively). Ex-smokers with asthma had a significant improvement in morning and night PEF (mean difference, 29.1; CI, 2.3, 56; p = 0.04 and 52.4; CI, 26, 79; p = 0.003, respectively), but not in FEV1 or asthma control score. We conclude that active smoking impairs the efficacy of short-term oral corticosteroid treatment in chronic asthma.<\/jats:p>","DOI":"10.1164\/rccm.200304-503oc","type":"journal-article","created":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T20:30:14Z","timestamp":1060029014000},"page":"1308-1311","source":"Crossref","is-referenced-by-count":353,"title":["Cigarette Smoking Impairs the Therapeutic Response to Oral Corticosteroids in Chronic Asthma"],"prefix":"10.1093","volume":"168","author":[{"given":"Rekha","family":"Chaudhuri","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, and Robertson Centre for Biostatistics and Biochemistry, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Livingston","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, and Robertson Centre for Biostatistics and Biochemistry, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex D.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, and Robertson Centre for Biostatistics and Biochemistry, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, and Robertson Centre for Biostatistics and Biochemistry, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Borland","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, and Robertson Centre for Biostatistics and Biochemistry, University of Glasgow, Glasgow, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil C.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department 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