{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:17:48Z","timestamp":1791310668459,"version":"4.3.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1987,8,1]],"date-time":"1987-08-01T00:00:00Z","timestamp":554774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We prospectively evaluated a protocol that included extravascular thermal volume (ETV) as a measure of extravascular lung water (EVLW) instead of pulmonary artery wedge pressure (Ppaw) measurements to guide the hemodynamic management of 48 critically ill patients. Patients were randomized to either a protocol management (PM), or to a routine management (RM) group. In the RM group, EVLW measurements were unknown to the primary care physicians. The 2 groups were similar with respect to age, gender, and severity of illness. In patients with initially high EVLW, EVLW fell to a greater extent in PM than in RM patients (18 \u00b1 5 versus 4 \u00b1 8% decrease, p &amp;lt; 0.05). This difference was even greater in patients with heart failure. No adverse effects on oxygenation or renal function occurred in following the protocol. Mortality for the groups as a whole was similar, but was significantly better (p &amp;lt; 0.05) for PM patients with initially high EVLW and normal Ppaw (predominantly patients with sepsis or the adult respiratory distress syndrome). For both groups, patients with an initial EVLW &amp;gt; 14 ml\/kg had a significantly greater mortality than did those with a lesser amount of EVLW: 13 of 15 (87%) versus 13 of 32 (41%), p &amp;lt; 0.05. We conclude that management based on a protocol using EVLW measurements is safe, may hasten the resolution of pulmonary edema, and may lead to improved outcome in some critically ill patients.<\/jats:p>","DOI":"10.1164\/ajrccm\/136.3.662","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T18:39:14Z","timestamp":1311273554000},"page":"662-668","source":"Crossref","is-referenced-by-count":168,"title":["A Prospective Study of Lung Water Measurements during Patient Management in an Intensive Care Unit"],"prefix":"10.1093","volume":"136","author":[{"given":"Paul R.","family":"Eisenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Hansbrough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixie","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1987,8,1]]},"reference":[{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198302033080508"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.7326\/0003-4819-103-3-445","volume":"103","author":"Robin ED","year":"1985","journal-title":"Ann Intern Med"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409133111106"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.5.593"},{"key":"p_23","first-page":"394","volume":"384","year":"1982","journal-title":"Sci"},{"key":"p_37","first-page":"685","volume":"89","year":"1986","journal-title":"Chest"},{"key":"p_41","first-page":"485","volume":"132","year":"1985","journal-title":"Respir Dis"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198212000-00002"},{"key":"p_60","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1148\/radiology.147.3.6342031","volume":"147","year":"1983","journal-title":"Radiology"},{"key":"p_79","first-page":"A398","volume":"133","year":"1986","journal-title":"Respir Dis"},{"key":"p_82","first-page":"976","volume":"12","year":"1984","journal-title":"Crit Care Med."},{"key":"p_89","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90199-5"},{"key":"p_92","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110049"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/136\/3\/662\/67746724\/ajrccm_136_3_662.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/136\/3\/662\/67746724\/ajrccm_136_3_662.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:24:21Z","timestamp":1775193861000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/136\/3\/662\/8557772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8,1]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1987,8,1]]},"published-print":{"date-parts":[[1987,8,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/136.3.662","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1987,8]]},"published":{"date-parts":[[1987,8,1]]}}}