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We applied high resolution computed tomography to 20 postmortem lung specimens fixed by a method that allows for direct one-to-one pathologic-radiologic correlation. The degree of centrilobuler emphysema was assessed radiologically on a visual grading system based on nonperipheral low-attenuation areas. The lungs were then sectioned along the plane of the CT image, and the degree of centrilobular emphysema was graded pathologically by scoring against a panel of standards. A significant correlation (r = 0.91, p &amp;lt; 0.005) was found between the pathologic grade and the in vitro CT score.<\/jats:p>","DOI":"10.1164\/ajrccm\/136.4.935","type":"journal-article","created":{"date-parts":[[2011,7,20]],"date-time":"2011-07-20T05:34:40Z","timestamp":1311140080000},"page":"935-940","source":"Crossref","is-referenced-by-count":157,"title":["High Resolution Computed Tomography of Inflation-fixed Lungs: Pathologic-Radiologic Correlation of Centrilobular Emphysema"],"prefix":"10.1093","volume":"136","author":[{"given":"Ralph H.","family":"Hruban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moulay A.","family":"Meziane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias A.","family":"Zerhouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagi F.","family":"Khouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot K.","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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