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The inhibitory effect was synergistic for the remaining 4 of 16 and 3 of 16 strains. This relationship reduced the minimal inhibitory concentrations for each drug in combination. In addition, the minimal bactericidal concentrations of all 3 drugs were reduced because of synergistic bactericidal activity in 6 of 6 strains tested.<\/jats:p>","DOI":"10.1164\/ajrccm\/137.3.711","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T16:56:03Z","timestamp":1365094563000},"page":"711-715","source":"Crossref","is-referenced-by-count":47,"title":["Combinations of Rifampin or Rifabutine plus Ethambutol against\n                    <i>Mycobacterium avium<\/i>\n                    Complex: Bactericidal Synergistic, and Bacteriostatic Additive or Synergistic Effects"],"prefix":"10.1093","volume":"137","author":[{"given":"Leonid B.","family":"Heifets","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Iseman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Lindholm-Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"key":"p_8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7326\/0003-4819-53-2-273","volume":"53","author":"Lewis AG","year":"1960","journal-title":"Ann Intern Med"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.133.1.59"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90792-7"},{"key":"p_21","first-page":"29","volume":"98","year":"1968","journal-title":"Dis"},{"key":"p_28","first-page":"547","volume":"108","year":"1973","journal-title":"Dis"},{"key":"p_47","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.1.148"},{"key":"p_60","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF01639043","volume":"8","year":"1980","journal-title":"Infection"},{"key":"p_68","first-page":"121","volume":"8","year":"1981","journal-title":"J Antimicrob Chemother"},{"key":"p_73","first-page":"180","year":"1986","journal-title":"Amsterdam: Excepta Medica"},{"key":"p_78","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.1.117"},{"key":"p_83","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.1.11"},{"key":"p_88","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.4.570"},{"key":"p_96","unstructured":"spiro-piperidyl-rifamycins. 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