{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T07:52:18Z","timestamp":1774857138185,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1988,3,1]],"date-time":"1988-03-01T00:00:00Z","timestamp":573177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) of rifabutine (ansamycin LM427, spiropiperidyl rifamycin) against rifampin-susceptible and rifampin-resistant strains of Mycobacterium tuberculosis were determined. The MICs for 17 rifampin-susceptible strains were low, falling in a narrow range of 0.06 \u00b5g\/ml or less when determined by either the agar-dilution method (in 7H10 or 7H11 agar) or in 7H12 broth (radiometrically or by sampling and colony-forming units [CFU\/ml] determination). The MICs of rifabutine for 21 rifampin-resistant strains were much higher, ranging from 0.25 to 16.0 \u00b5g\/ml. The MBCs of rifabutine were 0.125 or 0.25 \u00b5g\/ml for rifampin-susceptible strains, and were 4.0 and 32.0 \u00b5g\/ml for two tested rifampin-resistant strains. The MIC\/MBC ratio was 1:4 for rifampin-susceptible strains.<\/jats:p>","DOI":"10.1164\/ajrccm\/137.3.719","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T16:56:03Z","timestamp":1365094563000},"page":"719-721","source":"Crossref","is-referenced-by-count":32,"title":["Rifabutine: Minimal Inhibitory and Bactericidal Concentrations for\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1093","volume":"137","author":[{"given":"Leonid B.","family":"Heifets","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Lindholm-Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Iseman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,3,1]]},"reference":[{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.36.1502"},{"key":"p_22","first-page":"440","volume":"28","year":"1985","journal-title":"Chemother"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.4.570"},{"key":"p_32","first-page":"1278","volume":"132","year":"1985","journal-title":"Respir Dis"},{"key":"p_52","first-page":"710","volume":"132","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"p_60","first-page":"1067","volume":"115","year":"1977","journal-title":"Rev Respir Dis"},{"key":"p_65","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.27.1.11"},{"key":"p_81","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.2.349"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/137\/3\/719\/67639552\/ajrccm_137_3_719.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/137\/3\/719\/67639552\/ajrccm_137_3_719.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:50:38Z","timestamp":1774853438000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/137\/3\/719\/8556149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,1]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1988,3,1]]},"published-print":{"date-parts":[[1988,3,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/137.3.719","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1988,3]]},"published":{"date-parts":[[1988,3,1]]}}}