{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:45:25Z","timestamp":1775202325582,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1988,4,1]],"date-time":"1988-04-01T00:00:00Z","timestamp":575856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have examined the effects of indomethacin (I) on tolerance to the bronchomotor effects of repetitive challenge with exercise (EX) and eucapnic hyperpnea (EH) in 7 asthmatic subjects. Each subject was studied on 4 separate days. EH was performed for 4 min at a minute ventilation found previously to increase specific airway resistance (SRaw) by 8 units (cm H2O\/L\/s). All exercise challenges were performed on a cycle ergometer for 5 min at a constant work load. Subjects breathed room temperature, dry air for both stimuli. SRaw was serially measured before and after each stimulus. Tolerance was examined by giving up to 3 repetitions of EH or EX, allowing a return of SRaw to within 1 unit of baseline between repetitions. Placebo (P) or I (25 mg four times a day for 7 doses) was administered in a single-blind manner. The timing between stimulus repetitions on the P day was matched to that of the I day. After P, the initial rise in SRaw was similar for both EX and EH, with a significant and progressive decrease in this rise after each stimulus repetition (p = 0.032 for EX, p = 0.006 for EH). After I, tolerance was still demonstrated to EH (p = 0.002), but not to EX (p = 0.231). This finding indicates that EH and EX are not identical stimuli, since there is an I-sensitive mechanism (possibly a bronchodilating prostaglandin) associated with the development of tolerance to EX but not to EH. Our data also suggest a possible additional bronchoconstricting mechanism associated with EX and not with EH.<\/jats:p>","DOI":"10.1164\/ajrccm\/137.4.842","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T16:55:03Z","timestamp":1365094503000},"page":"842-846","source":"Crossref","is-referenced-by-count":37,"title":["Indomethacin Blocks Airway Tolerance to Repetitive Exercise but Not to Eucapnic Hyperpnea in Asthmatic Subjects"],"prefix":"10.1093","volume":"137","author":[{"given":"Dorothy J.","family":"Margolskee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara G.","family":"Bigby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homer A.","family":"Boushey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"p_2","first-page":"55","volume":"35","year":"1966","journal-title":"Quart I Med"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108954"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710062971402"},{"key":"p_32","first-page":"467","volume":"46","year":"1979","journal-title":"Physiol"},{"key":"p_36","first-page":"459","volume":"63","year":"1982","journal-title":"Eur I Respir Dis"},{"key":"p_63","first-page":"247","volume":"117","year":"1978","journal-title":"Rev Respir Dis"},{"key":"p_66","doi-asserted-by":"publisher","DOI":"10.1136\/thx.35.3.164"},{"key":"p_72","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90085-3"},{"key":"p_77","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1164\/arrd.1983.127.5.572","volume":"127","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"p_81","doi-asserted-by":"publisher","DOI":"10.1136\/thx.38.7.506"},{"key":"p_84","doi-asserted-by":"publisher","DOI":"10.1136\/thx.35.11.828"},{"key":"p_98","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90302-6"},{"key":"p_109","doi-asserted-by":"publisher","DOI":"10.1007\/BF00649355"},{"key":"p_113","doi-asserted-by":"publisher","DOI":"10.1007\/BF00499053"},{"key":"p_121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1984.tb10793.x"},{"key":"p_125","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1978.tb07005.x"},{"key":"p_127","first-page":"395","volume":"1","year":"1980","journal-title":"Science"},{"key":"p_137","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110528"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/137\/4\/842\/67748157\/ajrccm_137_4_842.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/137\/4\/842\/67748157\/ajrccm_137_4_842.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:34:21Z","timestamp":1775194461000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/137\/4\/842\/8556067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4,1]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1988,4,1]]},"published-print":{"date-parts":[[1988,4,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/137.4.842","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1988,4]]},"published":{"date-parts":[[1988,4,1]]}}}