{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:23:29Z","timestamp":1775921009054,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1988,4,1]],"date-time":"1988-04-01T00:00:00Z","timestamp":575856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Overnight polysomnography after acclimatization was performed on 14 patients with Duchenne muscular dystrophy (mean age, 18.3 yr; mean VC, 1.24 L). Despite their lack of sleep-related symptoms and normal daytime blood gas tensions, periods of hypopnea and\/or apnea (H\/A) were observed in all patients (mean frequency 9.6\/h; range, 3.7 to 17.0; mean duration 23.1; range of means, 16 to 36 s). In 9 patients, between 0.5 and 12.3 oxygen desaturations of &amp;gt; 5% occurred per hour, with falls from a mean SaO2 baseline of 95.4 \u00b1 0.6% (SEM) to a mean nadir of 74.2 \u00b1 3.9% (range, 58 to 90). This desaturating group (n = 9) showed longer and more frequent H\/A than did the 5 nondesaturators; the proportion of REM sleep occupied by H\/A was 37.7 \u00b1 3.8% in the desaturating group compared with only 15.1 \u00b1 5.1% in the remainder (p &amp;lt; 0.01). The severity of sleep-disordered breathing could not be reliably predicted from daytime pulmonary function test results, and only maximal static expiratory pressure appeared significantly lower in the desaturating group. Hypopneas were associated with reduced chest wall movement in all subjects, and with chest wall paradox in one; continued submental \u201cinspiratory\u201d EMG activity throughout \u201ccentral\u201d apneas in 2 subjects suggested that these episodes were not truly central in origin. Sleep hypoxemia is imputed in the progression of several chronic respiratory diseases, and its prevention in Duchenne and related neuromuscular diseases may influence morbidity and mortality.<\/jats:p>","DOI":"10.1164\/ajrccm\/137.4.884","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T16:55:03Z","timestamp":1365094503000},"page":"884-888","source":"Crossref","is-referenced-by-count":149,"title":["Hypoxemia during Sleep in Duchenne Muscular Dystrophy"],"prefix":"10.1093","volume":"137","author":[{"given":"Philip E. M.","family":"Smith","sequence":"first","affiliation":[{"name":"From the Muscle Research Centre, Department of Medicine, University of Liverpool, and the Mersey Regional Thoracic Unit, Fazakerley Hospital, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M. A.","family":"Calverley","sequence":"additional","affiliation":[{"name":"From the Muscle Research Centre, Department of Medicine, University of Liverpool, and the Mersey Regional Thoracic Unit, Fazakerley Hospital, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H. T.","family":"Edwards","sequence":"additional","affiliation":[{"name":"From the Muscle Research Centre, Department of Medicine, University of Liverpool, and the Mersey Regional Thoracic Unit, Fazakerley Hospital, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"p_3","first-page":"45","volume":"15","year":"1979","journal-title":"Physiopathol Respir"},{"key":"p_8","first-page":"295","year":"1978","journal-title":"Liss"},{"key":"p_15","first-page":"118","volume":"5","year":"1983","journal-title":"Neurol (Napoli)"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705073161906"},{"key":"p_52","first-page":"977","volume":"38","year":"1975","journal-title":"Psychiatry"},{"key":"p_56","first-page":"21","volume":"3","year":"1984","journal-title":"Cardiomyology"},{"key":"p_68","first-page":"1","year":"1978","journal-title":"New York:Alan R. 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