{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:46:31Z","timestamp":1775202391280,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1988,4,1]],"date-time":"1988-04-01T00:00:00Z","timestamp":575856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To determine whether lung elastin is lost during the evolution of cadmium-induced air-space enlargement with pulmonary fibrosis, the lung elastin of 5- to 7-day-old golden Syrian hamster pups was radiolabeled by giving [3H]valine. At maturity, a single intratracheal instillation of 0.5 ml of 0.025% CdCl2 solution was given. Lung mechanics, histologic examination, and biochemistry were studied 5, 10, 21, 42, 105, and 180 days after the cadmium treatment. The animals developed fibrosis and air-space enlargement with decreased lung volumes, compliance, and forced expiratory flow; their functional residual capacity was increased. The total lung collagen and total lung elastin were increased, but there was no loss of radiolabel in lung elastin. We conclude that CdCl2-induced air-space enlargement with pulmonary fibrosis is not accompanied by loss of neonatally formed lung elastic fibers. We hypothesize that air-space enlargement with fibrosis represents a stereotyped response of the lung to fibrosing injuries, which we hypothesize is due to forces from more fibrotic and atelectatic areas causing overdistension of less abnormal air spaces. The air-space enlargement of fibrosing human diseases such as sarcoidosis and eosinophilic granuloma may have a similar basis. Evidence is reviewed that human centrilobular emphysema may be a form of focal air-space enlargement with interstitial fibrosis; there may be mechanisms in addition to elastase-antielastase imbalance that cause human emphysema.<\/jats:p>","DOI":"10.1164\/ajrccm\/137.4.918","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T16:55:03Z","timestamp":1365094503000},"page":"918-923","source":"Crossref","is-referenced-by-count":52,"title":["Cadmium-Chloride-induced Air-Space Enlargement with Interstitial Pulmonary Fibrosis Is Not Associated with Destruction of Lung Elastin: Implications for the Pathogenesis of Human Emphysema"],"prefix":"10.1093","volume":"137","author":[{"given":"Gordon L.","family":"Snider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar C.","family":"Lucey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Faris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangja","family":"Jung-Legg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip J.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Franzblau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"With the technical assistance of Anthony Catanese, Mary P. McMahon, and Faith Barnard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"p_23","first-page":"139","volume":"18","year":"1980","journal-title":"Health"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1126\/science.7089570"},{"key":"p_46","first-page":"67","volume":"160","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.124"},{"key":"p_54","first-page":"303","volume":"672","year":"1981","journal-title":"Acta"},{"key":"p_77","doi-asserted-by":"publisher","DOI":"10.1007\/BF02715644"},{"key":"p_81","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109709"},{"key":"p_85","first-page":"441","volume":"135","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"p_92","first-page":"118","volume":"11","year":"1954","journal-title":"J Ind Med"},{"key":"p_108","doi-asserted-by":"publisher","DOI":"10.1136\/thx.12.3.219"},{"key":"p_115","first-page":"30","volume":"108","year":"1973","journal-title":"Iungs. Am Rev Respir Dis"},{"key":"p_118","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(61)90156-4"},{"key":"p_128","first-page":"291","volume":"1","year":"1972","journal-title":"Lancet"},{"key":"p_131","doi-asserted-by":"publisher","DOI":"10.1007\/BF00256348"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/137\/4\/918\/67748122\/ajrccm_137_4_918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/137\/4\/918\/67748122\/ajrccm_137_4_918.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:35:52Z","timestamp":1775194552000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/137\/4\/918\/8556105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4,1]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1988,4,1]]},"published-print":{"date-parts":[[1988,4,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/137.4.918","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1988,4]]},"published":{"date-parts":[[1988,4,1]]}}}