{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:52:25Z","timestamp":1775202745865,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We examined temperature-gradient and evaporative energy losses during cold gas inhalation challenges in patients with exercise-induced asthma by using gases with similar water-carrying capacities but significantly different volume heat capacities. Seven subjects were asked to hyperventilate mixtures of 80% helium\/20% oxygen (HeO2) or 80% sulfur hexafluoride\/20% oxygen (SF6O2) for 5 min at a fixed target minute ventilation of 20 \u00d7 FEV1 and an inspired gas temperature of 0\u00b0 C. Each subject equilibrated his or her lungs with the appropriate gas mixture prior to testing: Pet \u00a0CO2 and Fi \u00a0O2 were monitored and maintained at constant values (CO2 = 0.05; O2 = 0.20) by CO2 scrubbing and addition of compressed gas to the system. Gas composition, inspired and expired flow rates, and gas temperatures at the airway opening were recorded in real time using a computer-based data collection system that calculated respiratory heat loss on a per breath basis. Bronchoconstriction was quantitated using specific airway conductance measured before and serially after each challenge. The degree of bronchoconstriction correlated closely with evaporative respiratory heat loss (r = 0.658 p &amp;lt; 0.05), but poorly with both temperature-gradient (r = 0.114, p &amp;gt; 0.20) and total (r = 0.268, p &amp;gt; 0.15) heat loss. These findings suggest that total respiratory heat loss is not the primary stimulus in exercise-induced asthma, and further suggest that total water loss, or focal heat\/water toss, may be important in inducing bronchospasm in this subset of asthmatics.<\/jats:p>","DOI":"10.1164\/ajrccm\/138.3.540","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T16:59:15Z","timestamp":1365094755000},"page":"540-546","source":"Crossref","is-referenced-by-count":27,"title":["Dissociation of Temperature-Gradient and Evaporative Heat Loss during Cold Gas Hyperventilation in Cold-induced Asthma"],"prefix":"10.1093","volume":"138","author":[{"given":"E.","family":"Ingenito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Solway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lafleur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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