{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:12:08Z","timestamp":1774930328160,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1988,11,1]],"date-time":"1988-11-01T00:00:00Z","timestamp":594345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Overweight patients with obstructive sleep apnea (OSA) are improved by weight reduction, although the underlying mechanisms are not clear. We tested the hypothesis that improvement in OSA after weight loss is associated with improvement in pharyngeal function. Consequently, we measured pharyngeal area at functional residual capacity (AFRC) and at residual volume (ARV), the percent change in pharyngeal area between FRC and RV (\u0394Aph%) defined as (AFRC \u2212 ARV)\/AFRC \u00d7 100, and lung volume dependence of pharyngeal area (LVD) defined as the difference between AFRC and ARV normalized for the expiratory reserve volume (ERV)\u2014in 12 overweight apneic patients before and after weight loss. We found that after a 26 \u00b1 18 kg weight loss, there was a significant reduction in the apnea\/hypopnea index from 57 \u00b1 29 to 14 \u00b1 10 (p &amp;lt; 0.0005) and increase in the lowest nocturnal oxygen saturation from 54 \u00b1 20% to 80 \u00b1 8% (p &amp;lt; 0.001). This improvement was associated with a significant reduction in \u0394Aph% from 25 \u00b1 15% to 9 \u00b1 18% (p &amp;lt; 0.05) and a significant decrease in LVD from 1.98 \u00b1 1.52 cm2\/L to 0.16 \u00b1 0.88 cm2\/L (p &amp;lt; 0.005). There were four patients in whom baseline LVD was low and relatively unchanged after weight loss. Three of these patients exhibited paradoxical inspiratory narrowing of the glottis, which reversed after weight loss; these glottic abnormalities were not present in the rest of the patients with OSA. We conclude that improvement in obstructive sleep apnea after weight loss may be related to improvement in pharyngeal and glottic function.<\/jats:p>","DOI":"10.1164\/ajrccm\/138.5.1192","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T16:59:51Z","timestamp":1365094791000},"page":"1192-1195","source":"Crossref","is-referenced-by-count":101,"title":["Improvement in Upper Airway Function after Weight Loss in Patients with Obstructive Sleep Apnea"],"prefix":"10.1093","volume":"138","author":[{"given":"I.","family":"Rubinstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Colapinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. E.","family":"Rotstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. G.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Hoffstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,11,1]]},"reference":[{"key":"p_18","first-page":"211","volume":"132","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"p_21","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1152\/jappl.1978.44.6.931","volume":"44","year":"1978","journal-title":"J Appl Physiol"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611203152105"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1378\/chest.82.3.291"},{"key":"p_35","first-page":"850","volume":"103","year":"1985","journal-title":"Intern Med"},{"key":"p_41","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/jappl.1980.48.5.749","volume":"48","year":"1980","journal-title":"J Appl Physiol"},{"key":"p_45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/arrd.1984.130.2.175","volume":"130","year":"1984","journal-title":"Rev Respir Dis"},{"key":"p_53","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1152\/jappl.1984.57.5.1319","volume":"57","year":"1984","journal-title":"J Appl Physiol"},{"key":"p_65","first-page":"1158","volume":"53","year":"1982","journal-title":"Physiol"},{"key":"p_74","first-page":"375","volume":"63","year":"1987","journal-title":"Physiol"},{"key":"p_78","doi-asserted-by":"publisher","DOI":"10.1378\/chest.92.4.631"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/138\/5\/1192\/67663422\/ajrccm_138_5_1192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/138\/5\/1192\/67663422\/ajrccm_138_5_1192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:48:50Z","timestamp":1774925330000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/138\/5\/1192\/8560755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11,1]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1988,11,1]]},"published-print":{"date-parts":[[1988,11,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/138.5.1192","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1988,11]]},"published":{"date-parts":[[1988,11,1]]}}}