{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:49:46Z","timestamp":1787856586306,"version":"build-2784847793"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1989,3,1]],"date-time":"1989-03-01T00:00:00Z","timestamp":604713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eight consecutive patients (mean \u00b1 SD age, 43 \u00b1 11 yr) with acute severe asthma (status asthmaticus) requiring assisted ventilation were studied within the first 24 to 48 h of admission, at maintenance Fi \u00a0O2 and while breathing 100% O2, using the multiple inert gas elimination technique. Ventilation-perfusion ( \u00a0a\/) inequality was characterized by a marked bimodal blood flow distribution (perfusion to normal and low \u00a0a\/ populations) in all but two patients, with a mean of 27.6 \u00b1 12.3% of the total perfusion present in the low \u00a0a\/ ratio units (between 0.1 and 0.005). As a result, the dispersion of pulmonary blood flow distribution (log SDQ) was severely abnormal (mean, 1.65 \u00b1 0.28; normal range, 0.3 to 0.6). No patient had a substantial shunt ( \u00a0a\/ = 0) (mean value, 1.5 \u00b1 2.3%). The ventilation distribution was never bimodal, but the dispersion of the ventilation distribution (log SDV) was moderately elevated (1.01 \u00b1 0.24). High \u00a0a\/ areas (ventilation to \u00a0a\/ units between 10 and 100) were generally absent. While breathing 100% O2, PaO2, P \u00a0O2, and PaCO2 significantly rose, as did shunt and blood flow dispersion. Patients with life-threatening acute severe asthma treated by mechanical ventilation show: (1) the most abnormal gas exchange characteristics of the \u00a0a\/ spectrum observed to date in human asthma but essentially the same pattern as in patients with less severe disease; (2) a high level of hypoxic pulmonary vascular response; (3) a significant amount of shunt while breathing 100% O2, suggesting the presence of absorption atelectasis or redistribution of blood flow.<\/jats:p>","DOI":"10.1164\/ajrccm\/139.3.732","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:03:18Z","timestamp":1365094998000},"page":"732-739","source":"Crossref","is-referenced-by-count":79,"title":["Mechanisms of Hypoxemia in Patients with Status Asthmaticus Requiring Mechanical Ventilation"],"prefix":"10.1093","volume":"139","author":[{"given":"Robert","family":"Rodriguez-Roisin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeni","family":"Ballester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1989,3,1]]},"reference":[{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1136\/thx.41.6.459"},{"key":"p_7","first-page":"377","volume":"80","year":"1987","journal-title":"Immunol"},{"key":"p_9","first-page":"1028","volume":"278","author":"Engl","year":"1968","journal-title":"Med"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.2.167"},{"key":"p_28","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1164\/ajrccm\/137.5.1055","volume":"137","year":"1988","journal-title":"Respir Dis"},{"key":"p_29","first-page":"A255","volume":"135","author":"Ballester E","year":"1987","journal-title":"Am RevRespir Dis"},{"key":"p_47","first-page":"525","volume":"118","year":"1978","journal-title":"Respir Dis"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.225"},{"key":"p_68","first-page":"A352","volume":"131","year":"1985","journal-title":"Respir Dis"},{"key":"p_71","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1152\/jappl.1966.21.4.1375","volume":"21","year":"1966","journal-title":"Appl Physiol"},{"key":"p_95","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(69)90071-1"},{"key":"p_107","first-page":"745","volume":"47","year":"1979","journal-title":"Physiol"},{"key":"p_125","first-page":"A307","volume":"135","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"p_134","first-page":"A271","volume":"137","year":"1988","journal-title":"Respir Dis"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/139\/3\/732\/67749928\/ajrccm_139_3_732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/139\/3\/732\/67749928\/ajrccm_139_3_732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:57:52Z","timestamp":1775195872000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/139\/3\/732\/8560170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3,1]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1989,3,1]]},"published-print":{"date-parts":[[1989,3,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/139.3.732","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1989,3]]},"published":{"date-parts":[[1989,3,1]]}}}