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Exercise is associated with increased ventilatory demand and midexpiratory glottic widening in healthy subjects. However, the relative contribution of glottic aperture to airflow limitation during exercise-induced asthma is unknown. Consequently, we used the acoustic reflection technique to test whether a decrease in midexpiratory glottic size occurred also during exercise-induced bronchoconstriction in seven asthmatic subjects. Exercise resulted in a 38 \u00b1 16% (SD) fall in FEV1 from the baseline value (p &amp;lt; 0.001) and a significant increase in midexpiratory glottic cross-sectional area from 1.89 \u00b1 0.45 cm2 before to 2.36 \u00b1 0.71 cm2 during bronchoconstriction (p &amp;lt; 0.05). This midexpiratory glottic widening was also associated with increased tidal flow rates. We conclude that in marked contrast to airway obstruction induced by histamine or methacholine, exercise-induced asthma is associated with midexpiratory glottic widening, which occurs concomitantly with a decrease in lower airway caliber. We suggest that modulation of glottic aperture during acute asthma is heterogeneous and depends partly on the initiating stimulus.<\/jats:p>","DOI":"10.1164\/ajrccm\/140.3.606","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:04:30Z","timestamp":1365095070000},"page":"606-609","source":"Crossref","is-referenced-by-count":6,"title":["Expiratory Glottic Widening in Asthmatic Subjects during Exercise-induced Bronchoconstriction"],"prefix":"10.1093","volume":"140","author":[{"given":"I.","family":"Rubinstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Slutsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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