{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:09:27Z","timestamp":1776186567706,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1989,10,1]],"date-time":"1989-10-01T00:00:00Z","timestamp":623203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We examined the relationship between changes in systemic oxygen transport (SO2T) and mixed venous PO2 (P \u00a0O2) in nine critically ill patients with acute respiratory failure and analyzed the effect of like and opposite changes in cardiac output (CO) and arterial PO2 (PaO2) on this relationship. Paired measurements of oxygen consumption ( \u00a0O2), SO2T, and P \u00a0O2 were obtained before and after changes in the level of positive end-expiratory pressure (PEEP) equal to or more than 5 cm H2O. \u00a0O2 was measured with a rebreathing circuit adapted to a volume ventilator, and SO2T was calculated from thermodilution CO, PaO2, SaO2, and hemoglobin. In eight studies, CO and PaO2 changed in the same direction, and the absolute change in SO2T averaged 48 \u00b1 38 ml\/min\/m2. In 12 studies, CO and PaO2 changed in opposite directions, and the absolute change in SO2T averaged 78 \u00b1 69 ml\/min\/m2. When PaO2 and CO changed in the same direction, P \u00a0O2 increased on the higher level of SO2T (average difference 3.0 \u00b1 3.7 mm Hg, p &amp;lt; 0.05) and there was a strong positive correlation between the difference in SO2T on lower and higher levels of PEEP and the difference in P \u00a0O2 (r = 0.83). When PaO2 and CO changed in opposite directions, P \u00a0O2 was unchanged on the higher level of SO2T, and there was no correlation between the difference in SO2T on lower and higher levels of PEEP and the difference in P \u00a0O2 (r = \u22120.45). \u00a0O2 was not different at the lower and higher levels of SO2T in both groups, indicating that \u00a0O2 was not transport-limited in these patients. We conclude that unidirectional changes in CO and PaO2 produce like changes in P \u00a0O2, whereas the relationship between SO2T and P \u00a0O2 is inconsistent when opposite changes in CO and PaO2 occur.<\/jats:p>","DOI":"10.1164\/ajrccm\/140.4.891","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:10:25Z","timestamp":1365095425000},"page":"891-898","source":"Crossref","is-referenced-by-count":39,"title":["Effect of Opposite Changes in Cardiac Output and Arterial PO2 on the Relationship between Mixed Venous PO2 and Oxygen Transport"],"prefix":"10.1093","volume":"140","author":[{"given":"Paul V.","family":"Carlile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry A.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1989,10,1]]},"reference":[{"key":"p_4","first-page":"387","volume":"122","year":"1980","journal-title":"Rev Respir Dis"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.3.267"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.92.3.447"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.3.336"},{"key":"p_28","first-page":"397","volume":"317","author":"N","year":"1987","journal-title":"Med"},{"key":"p_45","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/arrd.1984.129.5.682","volume":"129","year":"1984","journal-title":"Rev Respir Dis"},{"key":"p_47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1164\/arrd.1983.128.1.30","volume":"128","author":"Independence BG.","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"p_59","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1152\/jappl.1979.46.3.599","volume":"46","year":"1979","journal-title":"Appl Physiol"},{"key":"p_63","first-page":"36","volume":"44","year":"1978","journal-title":"Physiol"},{"key":"p_76","first-page":"296","volume":"193","year":"1981","journal-title":"Surg"},{"key":"p_92","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197202242860806"},{"key":"p_97","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107786"},{"key":"p_100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1152\/jappl.1988.65.2.601","volume":"65","year":"1988","journal-title":"Appl Physiol"},{"key":"p_113","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1152\/jappl.1973.34.5.573","volume":"34","year":"1973","journal-title":"J Appl Physiol"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/140\/4\/891\/67650943\/ajrccm_140_4_891.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/140\/4\/891\/67650943\/ajrccm_140_4_891.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:01:46Z","timestamp":1774864906000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/140\/4\/891\/8559123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10,1]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1989,10,1]]},"published-print":{"date-parts":[[1989,10,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/140.4.891","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1989,10]]},"published":{"date-parts":[[1989,10,1]]}}}