{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:43:08Z","timestamp":1790966588420,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study we evaluated the disease specificity of bronchoalveolar lavage fluid angiotensin-converting enzyme (BALF-ACE), its correlation with cellular constituents of bronchoalveolar lavage fluid (BALF), and for sarcoidosis, with other proposed markers of disease activity. Furthermore, the question of the clinical value of BALF-ACE determinations in interstitial lung diseases or any of its subgroups was addressed. The study population consisted of 222 patients, 69 with biopsy proven sarcoidosis, 3 with hypersensitivity pneumonitis, 4 with acute histoplasmosis, 27 with idiopathic pulmonary fibrosis (IPF), 4 with rheumatoid arthritis-related interstitial fibrosis, 9 with pulmonary drug toxicity, 16 with pulmonary malignancies, 26 with other parenchymal lung disease entities, and 30 in whom the final diagnosis remained indeterminate. Elevated BALF-ACE concentrations were seen in all diagnostic categories. in sarcoidosls BALFACE levels correlated well with lavage lymphocyte counts (r = 0.49; p &amp;lt; 0.0001), in contrast to IPF where they correlated well with lavage neutrophil counts (r = 0.51; p &amp;lt; 0.007). The correlation of BALF-ACE with serum-ACE was significant. In sarcoidosis the mean BALF-ACE level was lower for patients with Stage-I chest roentgenographic patterns (0.664 U\/L), compared to those with Stage II (1.112 U\/L) and Stage III (1.083 U\/L). It was concluded that elevated BALF-ACE levels are not specific for sarcoidosis. The correlations of BALF-ACE levels with different cellular constituents of BALF suggest a different cellular origin of BALF-ACE. In sarcoidosis BALF-ACE levels correlate well with other proposed markers of disease activity and seem to reflect pulmonary activity better than serum ACE. However, the clinical usefulness of BALF-ACE determinations cannot be supported.<\/jats:p>","DOI":"10.1164\/ajrccm\/141.1.117","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:10:48Z","timestamp":1365095448000},"page":"117-123","source":"Crossref","is-referenced-by-count":67,"title":["Bronchoalveolar Lavage Fluid Angiotensin-converting Enzyme in Interstitial Lung Diseases"],"prefix":"10.1093","volume":"141","author":[{"given":"Ulrich","family":"Specks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"William J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Rohrbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"p_5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJM198401193100304","volume":"310","year":"1984","journal-title":"N Engl J Moo"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.90.6.791"},{"key":"p_35","first-page":"365","volume":"59","year":"1975","journal-title":"J Moo"},{"key":"p_36","first-page":"761","volume":"119","author":"Rohrbach MS","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"p_56","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.1.19"},{"key":"p_60","doi-asserted-by":"publisher","DOI":"10.1136\/thx.40.7.497"},{"key":"p_64","first-page":"790","volume":"34","year":"1981","journal-title":"Thorax"},{"key":"p_68","doi-asserted-by":"publisher","DOI":"10.1159\/000194479"},{"key":"p_80","doi-asserted-by":"publisher","DOI":"10.1159\/000194833"},{"key":"p_84","doi-asserted-by":"publisher","DOI":"10.1136\/thx.41.8.629"},{"key":"p_96","first-page":"272","volume":"84","year":"1978","journal-title":"Biochem"},{"key":"p_99","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.1.128"},{"key":"p_104","first-page":"355","volume":"64","year":"1983","journal-title":"Eur J Respir Dis"},{"key":"p_107","first-page":"64","volume":"57","year":"1982","journal-title":"Mayo Clin Proc"},{"key":"p_113","first-page":"266","volume":"128","year":"1983","journal-title":"Dis"},{"key":"p_118","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1152\/jappl.1986.60.2.532","volume":"60","year":"1986","journal-title":"J Appl Physiol"},{"key":"p_122","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/arrd.1987.135.6.1276","volume":"135","year":"1987","journal-title":"Rev Respir Dis"},{"key":"p_129","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.6.856"},{"key":"p_132","doi-asserted-by":"publisher","DOI":"10.1378\/chest.87.6.740"},{"key":"p_136","first-page":"244","volume":"70","year":"1978","journal-title":"Pathol"},{"key":"p_151","first-page":"129","year":"1988","journal-title":"BV"},{"key":"p_156","first-page":"1","volume":"124","year":"1981","journal-title":"Respir Dis"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/141\/1\/117\/67752835\/ajrccm_141_1_117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/141\/1\/117\/67752835\/ajrccm_141_1_117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:11:19Z","timestamp":1775196679000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/141\/1\/117\/8558493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1,1]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1990,1,1]]},"published-print":{"date-parts":[[1990,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/141.1.117","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1990,1]]},"published":{"date-parts":[[1990,1,1]]}}}