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Apnea duration (APD), arterial oxygen saturation changes (\u0394SaO2), and the percentage of heart rate changes (\u0394HR%) during PB with apnea were analyzed. The data were compared with hypoxic heart rate and ventilatory responses assessed at sea level. HR during the apneic period (APD, 10, 8 \u00b1 1.2 s; \u0394SaO2, 10.2 \u00b1 1.8%) was significantly smaller than that during the ventilatory period of PB (56.0 \u00b1 5.1\/min and 74.6 \u00b1 6.2\/min, respectively). This HR slowing or acceleration alternated in accordance with off and on activities in ventilation. The magnitude of \u0394HR% had a significant correlation with that of \u0394SaO2 (P &amp;lt; 0.01). The sensitivity of HR depression to desaturation (\u0394HR%\/\u0394SaO2) was smaller in low HVR climbers than in high HVR climbers. We concluded that these results can be ascribed to the fact that the primary effect of peripheral chemoreceptors on the cardiovascular center is vagotonia, and the effect is overridden by the vagal pulmonary inflation reflex.<\/jats:p>","DOI":"10.1164\/ajrccm\/141.1.39","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:10:48Z","timestamp":1365095448000},"page":"39-42","source":"Crossref","is-referenced-by-count":29,"title":["Heart Rate Depression during Sleep Apnea Depends on Hypoxic Chemosensitivity: A Study at High Altitude"],"prefix":"10.1093","volume":"141","author":[{"given":"S.","family":"Masuyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kohchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Okita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"p_8","unstructured":"sponse during apnea. 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