{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:13:56Z","timestamp":1774926836953,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1990,6,1]],"date-time":"1990-06-01T00:00:00Z","timestamp":644198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The adult respiratory distress syndrome (ARDS) is often characterized by a neutrophilic alveolitis, which may be mediated in part by the neutrophil chemoattractant, C5a. Chemotactic factor inactivator (CFI) can decrease C5a-directed neutrophil chemotaxis. Thus, a loss of CFI activity in the ARDS lung could lead to an increased ability of C5a to attract neutrophils. Lung CFI levels were measured antigenically and functionally in bronchoalveolar lavage (BAL) fluid obtained from 29 patients with ARDS and in 14 normal control subjects. Antigenic levels of CFI were found to be markedly elevated in ARDS BAL fluid (1,855 \u00b1 437 ng\/ml) compared with that in normal BAL (29 \u00b1 10 ng\/ml, p &amp;lt; 0.005), but, in contrast, CFI functional activity was markedly decreased in ARDS BAL fluid compared with that in normal BAL fluid (31 \u00b1 7% inhibition versus 76 \u00b1 5% inhibition, p &amp;lt; 0.01). Furthermore, although purified CFI readily inhibited the ability of C5a to attract neutrophils (92% inhibition), this activity was decreased when BAL fluid from patients with ARDS was incubated with CFI (47 \u00b1 10%, p &amp;lt; 0.01). These findings suggest that patients with ARDS are functionally deficient in CFI, leading to an increased ability of C5a to attract neutrophils.<\/jats:p>","DOI":"10.1164\/ajrccm\/141.6.1463","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:12:19Z","timestamp":1365095539000},"page":"1463-1468","source":"Crossref","is-referenced-by-count":6,"title":["Functional Loss of Chemotactic Factor Inactivator in the Adult Respiratory Distress Syndrome"],"prefix":"10.1093","volume":"141","author":[{"given":"Richard","family":"Robbins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Maunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Gossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Rennard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,6,1]]},"reference":[{"key":"p_12","first-page":"104","volume":"2","year":"1982","journal-title":"Respir Med"},{"key":"p_17","first-page":"218","volume":"133","year":"1986","journal-title":"Dis"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101223040402"},{"key":"p_33","first-page":"1098","volume":"132","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"p_41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110374"},{"key":"p_45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110823"},{"key":"p_51","first-page":"900","volume":"306","author":"Engl","year":"1982","journal-title":"Med"},{"key":"p_71","first-page":"17","volume":"93","year":"1979","journal-title":"Lab Clin Med"},{"key":"p_76","first-page":"292","volume":"110","year":"1987","journal-title":"Lab Clin Med"},{"key":"p_79","unstructured":"ratory distress syndrome. 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