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Despite the presence of a regular respiratory pattern during wakefulness, NREM sleep was associated with the appearance of a sustained periodic respiratory pattern characterized by clusters of usually two breaths separated by an 8 to 10-s expiratory pause. At sleep onset, this Biot's respiratory pattern appeared immediately after a sigh. Breathing frequency during NREM sleep became regular with administration of supplemental O2 and an attendant increase in end-tidal CO2. Shortly after withdrawal of supplemental O2 during NREM sleep, the periodic pattern resumed and was again immediately preceded by a sigh. The observations during NREM sleep in this patient with a central nervous system abnormality indicate that Biot's type respiratory pattern may be reversed by administration of supplemental oxygen. The results in this patient suggest: (1) the presence of a very elevated CO2 apnea threshold, and (2) that the pons may play a role in determining the effect of hypercapnic hypoxia on respiratory pattern during sleep.<\/jats:p>","DOI":"10.1164\/ajrccm\/142.4.880","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:21:14Z","timestamp":1365096074000},"page":"880-883","source":"Crossref","is-referenced-by-count":16,"title":["Hypercarbic Periodic Breathing during Sleep in a Child with a Central Nervous System Tumor"],"prefix":"10.1093","volume":"142","author":[{"given":"Samuel T.","family":"Kuna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Smickley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley C.","family":"Murchison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,10,1]]},"reference":[{"key":"p_3","first-page":"915","volume":"109","year":"1963","journal-title":"Sci"},{"key":"p_5","first-page":"32","year":"1980","journal-title":"Philadelphia: FA Davis"},{"key":"p_17","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1152\/jappl.1986.61.4.1293","volume":"61","year":"1986","journal-title":"J Appl Physiol"},{"key":"p_22","first-page":"223","year":"1986","journal-title":"American Physiological Society"},{"key":"p_24","first-page":"265","volume":"10","year":"1989","journal-title":"Curr Pulmonol"},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1963.tb02717.x"},{"key":"p_41","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/sleep\/6.3.234","volume":"6","year":"1983","journal-title":"Sleep"},{"key":"p_43","first-page":"230","volume":"12","year":"1971","journal-title":"RespirPhysiol"},{"key":"p_47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1981.tb06747.x"},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1007\/BF02240461"},{"key":"p_54","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1152\/jappl.1975.39.2.209","volume":"39","year":"1975","journal-title":"J Appl Physiol"},{"key":"p_65","first-page":"1163","volume":"133","year":"1986","journal-title":"Dis"},{"key":"p_68","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/jappl.1983.55.3.813","volume":"55","year":"1983","journal-title":"J Appl Physiol"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/142\/4\/880\/67753380\/ajrccm_142_4_880.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/142\/4\/880\/67753380\/ajrccm_142_4_880.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:15:51Z","timestamp":1775196951000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/142\/4\/880\/8558345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10,1]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1990,10,1]]},"published-print":{"date-parts":[[1990,10,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/142.4.880","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1990,10]]},"published":{"date-parts":[[1990,10,1]]}}}