{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:40:33Z","timestamp":1776987633721,"version":"3.51.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We examined effects of early post-treatment with the methylxanthine pentoxifylline (PTXF), or the cell-permeable adenosine 3\u2032, 5\u2032-cyclic monophosphate (cAMP) analog dibutyryl cAMP (db-cAMP) on Escherichia-coli-induced acute lung injury in guinea pigs. Acute lung injury was assessed by measurements of lung water (lung wet\/dry weight ratio; W\/D ratio), the concentration ratio of 125I-albumin in bronchoalveolar lavage (BAL) fluid and lung tissue compared with plasma (albumin index; BAL-AI or tissue-AI), and total differential leukocyte count in BAL fluid. Mean arterial pressure (Pa) and peripheral WBC counts were monitored continuously over the 8-h experiment. Septicemia was induced by a bolus injection of 2 \u00d7 109\/kg live E. coli. Thirty minutes later the animals received a bolus injection followed by continuous infusion of PTXF (20 mg\/kg + 20 mg\/kg\/h; n = 8) or db-cAMP (2 mg\/kg + 2 mg\/kg\/h; n = 8) or saline (septic control; n = 8). Nonseptic control groups were also studied. The lung W\/D ratio, BAL-AI, lung tissue-AI, and BAL leukocyte count increased significantly in the septic control group. The PTXF-septic and db-cAMP-septic groups showed no significant increase in lung W\/D ratio, BAL-AI, and lung tissue-AI. However, there was no difference in BAL total and differential leukocyte count as compared with the septic control group. PTXF and db-cAMP had no effect on E. coli-induced changes in peripheral WBC count and Pa. Companion in vitro experiments demonstrated that PTXF and db-cAMP inhibited the endotoxin-induced (E. coli) chemiluminescent response of isolated guinea-pig polymorphonuclear leukocytes (PMN). These results indicate that early post-treatment with PTXF or db-cAMP attenuates E. coli- induced acute lung injury in guinea pigs. Because PTXF and db-cAMP markedly reduce endotoxin-induced PMN chemiluminescence, they may attenuate acute lung injury in part by inhibiting PMN activation. Additionally, because PTXF and db-cAMP were administered after the septic insult, they may have therapeutic potential.<\/jats:p>","DOI":"10.1164\/ajrccm\/143.2.289","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:23:07Z","timestamp":1365096187000},"page":"289-293","source":"Crossref","is-referenced-by-count":29,"title":["Early Post-Treatment with Pentoxifylline or Dibutyryl cAMP Attenuates\n                    <i>Escherichia coli<\/i>\n                    -induced Acute Lung Injury in Guinea Pigs"],"prefix":"10.1093","volume":"143","author":[{"given":"Hans","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Hatherill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Yonemaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitoshi","family":"Ishizaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Raffin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"p_3","first-page":"505","volume":"60","year":"1984","journal-title":"Med J"},{"key":"p_7","first-page":"247","year":"1986","journal-title":"Critical Care Medicine"},{"key":"p_12","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1164\/ajrccm\/142.4.782","volume":"142","author":"Hoffmann H","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"p_19","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1164\/ajrccm\/140.4.974","volume":"140","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"p_26","first-page":"251","volume":"17","author":"AMP.","year":"1975","journal-title":"J Reticuloendothel Soc"},{"key":"p_34","first-page":"146","volume":"46","year":"1979","journal-title":"Physiol"},{"key":"p_42","first-page":"256","volume":"131","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"p_47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4049\/jimmunol.111.1.27","volume":"111","year":"1973","journal-title":"J Immunol"},{"key":"p_64","first-page":"401","volume":"73","year":"1973","journal-title":"Surgery"},{"key":"p_69","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1164\/ajrccm\/137.4.783","volume":"137","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"p_78","first-page":"283","volume":"7","year":"1985","journal-title":"Biophys"},{"key":"p_83","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(75)90062-3"},{"key":"p_88","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.9"},{"key":"p_101","first-page":"211","volume":"51","year":"1978","journal-title":"J Pharmacol"},{"key":"p_112","first-page":"1569","volume":"39","year":"1980","journal-title":"Fed Proc"},{"key":"p_115","doi-asserted-by":"publisher","DOI":"10.1038\/294451a0"},{"key":"p_124","first-page":"254","volume":"112","year":"1988","journal-title":"J Lab Clin Med"},{"key":"p_133","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)81271-3"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/143\/2\/289\/67753915\/ajrccm_143_2_289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/143\/2\/289\/67753915\/ajrccm_143_2_289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:18:37Z","timestamp":1775197117000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/143\/2\/289\/8557917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2,1]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1991,2,1]]},"published-print":{"date-parts":[[1991,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/143.2.289","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1991,2]]},"published":{"date-parts":[[1991,2,1]]}}}