{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:19:15Z","timestamp":1775204355049,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preapneic thoracic gas volume (Vtg), arterial saturation (SaO2), and mixed venous oxygen saturation (S \u00a0O2), have been shown to influence the rate of SaO2 fall (dSaO2\/dt) during apnea. We asked the following question: does tissue oxygen consumption (t \u00a0O2) affect the dSaO2\/dt during apnea? We attempted to answer this question by comparing dSaO2\/dt during obstructive apneas (high t \u00a0O2) with dSaO2\/dt during nonobstructive apneas (low t \u00a0O2) in six adult baboons. Fiberoptic central venous and arterial catheters were used for continuous monitoring of S \u00a0O2, SaO2, and cardiac output. A sapphire-bearing turbine monitored minute ventilation and airflow cessation. A Respitrace\u00ae and esophageal pressures were used to assess relative differences in Vtg. Obstructive apneas (30, 45, and 60-s) were created by clamping an indwelling cuffed endotracheal tube at end-expiration. Nonobstructive apneas were created by paralyzing the animals with atracurium and interrupting ventilation for periods equivalent to those of the obstructed apneas. The ventilator was adjusted to duplicate the respiratory rate, tidal volume, and relative Vtg of the spontaneously breathing animal. Mean t \u00a0O2 during spontaneous breathing was 110 ml\/min (Fick method) and decreased to 90 ml\/min during paralysis (p &amp;lt; 0.05). The dSaO2\/dt for the three apnea durations (mean, all animals), obstructive versus nonobstructed were: 0.85 and 0.74%\/s (n = 6), 0.87 and 0.75%\/s (n = 6), and 0.60 and 0.48%\/s (n = 4), respectively. The dSaO2\/dt was significantly lower during the nonobstructive apneas. We conclude that differences in \u00a0O2 during apnea may affect the dSaO2\/dt and that for the same duration apnea, central apneas may show less desaturation than obstructive apneas where vigorous muscular efforts at overcoming obstruction are common.<\/jats:p>","DOI":"10.1164\/ajrccm\/143.3.657","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:24:08Z","timestamp":1365096248000},"page":"657-660","source":"Crossref","is-referenced-by-count":13,"title":["Rate of Oxyhemoglobin Desaturation in Obstructive versus Nonobstructive Apnea"],"prefix":"10.1093","volume":"143","author":[{"given":"Eugene C.","family":"Fletcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Goodnight-White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Munafo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Charles C.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Luckett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,3,1]]},"reference":[{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.4.717"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1063\/1.344402"},{"key":"p_20","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1152\/jappl.1988.64.5.2220","volume":"64","year":"1988","journal-title":"J Appl Physiol"},{"key":"p_27","first-page":"259","volume":"117","year":"1978","journal-title":"Respir Dis"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.2.452"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/143\/3\/657\/67753863\/ajrccm_143_3_657.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/143\/3\/657\/67753863\/ajrccm_143_3_657.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:17:40Z","timestamp":1775197060000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/143\/3\/657\/8557974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3,1]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1991,3,1]]},"published-print":{"date-parts":[[1991,3,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/143.3.657","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1991,3]]},"published":{"date-parts":[[1991,3,1]]}}}