{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:21:48Z","timestamp":1774862508324,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1991,8,1]],"date-time":"1991-08-01T00:00:00Z","timestamp":681004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The flow and volume dependence of the total resistance of the respiratory system (Rrs) was investigated in six mechanically ventilated patients with chronic obstructive pulmonary disease (COPD) using a simple, rapid method. Isovolume Rrs-flow () relationships obtained at different inflation volumes (range 0.1 to 1 L) fitted (p &amp;lt; 0.001) the following function: Rrs = a\/ + b + c, where a, b, and c are constants. The term \u201ca\/\u201d in this equation represents the hyperbolic decrease in thoracic tissue resistance with increasing flow; the term \u201cc\u201d represents the linear increase in airway resistance with increasing flow. Rrs initially decreased with increasing because at low flow the weight of the a\/ was greater than that of the c. At higher flow, however, c became predominant and hence Rrs tended to increase. At an inflation volume of 0.5 L, minimum Rrs occurred at average inflation flow of 1.28 L\/s. At low flow, Rrs increased progressively with increasing inflation volume; at inflation &amp;gt; 1 L\/s, the highest values of Rrs were obtained at low inflation volumes. The flow and volume dependence of Rrs implies that, for comparative purposes, measurements of Rrs should be standardized to a fixed inflation flow and volume.<\/jats:p>","DOI":"10.1164\/ajrccm\/144.2.384","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T16:17:08Z","timestamp":1312388228000},"page":"384-389","source":"Crossref","is-referenced-by-count":36,"title":["Flow Resistance in Patients with Chronic Obstructive Pulmonary Disease in Acute Respiratory Failure: Effects of Flow and Volume"],"prefix":"10.1093","volume":"144","author":[{"given":"C.","family":"Tantucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Corbeil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chass\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Braidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Matar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Milic-Emili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,8,1]]},"reference":[{"key":"p_5","first-page":"355","volume":"138","year":"1988","journal-title":"Dis"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1152\/jappl.1985.58.6.1849","volume":"58","year":"1985","journal-title":"J Appl Physiol"},{"key":"p_18","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1152\/jappl.1989.67.6.2556","volume":"67","year":"1989","journal-title":"J Appl Physiol"},{"key":"p_37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1152\/jappl.1988.64.1.441","volume":"64","year":"1988","journal-title":"J Appl Physiol"},{"key":"p_42","first-page":"672","volume":"131","year":"1985","journal-title":"Dis"},{"key":"p_50","first-page":"411","year":"1964","journal-title":"American Physiological Society"},{"key":"p_66","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950060105"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/144\/2\/384\/67644226\/ajrccm_144_2_384.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/144\/2\/384\/67644226\/ajrccm_144_2_384.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:39:19Z","timestamp":1774859959000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/144\/2\/384\/8557513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1991,8,1]]},"published-print":{"date-parts":[[1991,8,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/144.2.384","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1991,8]]},"published":{"date-parts":[[1991,8,1]]}}}