{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:26:12Z","timestamp":1775204772154,"version":"3.50.1"},"reference-count":2,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate whether survivors of heart\/lung and double-lung transplantations have normal or increased nonspecific bronchial responsiveness, nine heart\/lung and four double-lung transplant recipients with normal lung histology underwent methacholine challenge and voluntary isocapnic dry air hyperventilation (VIH) in a randomized order at a mean time of 14.8 \u00b1 12.1 months after surgery. Transplant recipients were compared with 10 normal subjects and 11 patients with mild asthma. Asthmatic patients had a mean provocative concentration of methacholine inducing a 20% fall (PC20) in FEV1 of 3.4 \u00b1 3.6 mg\/ml (SD). Seventy seven percent of the transplant recipients and 70% of the normal subjects had PC20 superior to 32 mg\/ml. The percentage fall from baseline FEV1 after VIH was 12.6 \u00b1 10.4% in asthmatic patients as compared with 1.9 \u00b1 2.9% in transplant recipients (p = 0.002) and 0.45 \u00b1 1.2% in normal subjects (p = 0.001). The decrease in FEV1 after VIH was similar in transplant recipients and normal subjects (p = 0.14). These results show that heart\/lung or double-lung transplant recipients with normal lung histology have a normal response to nonspecific bronchial stimulation.<\/jats:p>","DOI":"10.1164\/ajrccm\/145.6.1503","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:35:46Z","timestamp":1365096946000},"page":"1503-1505","source":"Crossref","is-referenced-by-count":17,"title":["Lack of Bronchial Hyperresponsiveness to Methacholine and to Isocapnic Dry Air Hyperventilation in Heart\/Lung and Double-lung Transplant Recipients with Normal Lung Histology"],"prefix":"10.1093","volume":"145","author":[{"given":"Philippe","family":"Herve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Picard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Le Roy Ladurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Silbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Cerrina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Le Roy Ladurie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Chapelier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Dartevelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Simonneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Parquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Brenot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Duroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"And The Paris-Sud Lung Transplant Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,6,1]]},"reference":[{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1378\/chest.97.6.1360"},{"key":"p_45","first-page":"477","volume":"19","year":"1983","journal-title":"Respir"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/145\/6\/1503\/67755043\/ajrccm_145_6_1503.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/145\/6\/1503\/67755043\/ajrccm_145_6_1503.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:25:31Z","timestamp":1775197531000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/145\/6\/1503\/8557827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6,1]]},"references-count":2,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1992,6,1]]},"published-print":{"date-parts":[[1992,6,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/145.6.1503","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1992,6]]},"published":{"date-parts":[[1992,6,1]]}}}