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We have examined that hypothesis using a neutralizing antibody to IL-5 in ovalbumin-sensitized guinea pigs challenged with aerosolized antigen. The extent of eosinophilia has been quantitated in bronchoalveolar lavage (BAL) and by histologic evaluation of lung tissue sections. Acute intraperitoneal administration of a rat IgG1 monoclonal antibody to murine IL-5 derived from TRFK-5 cells prevented lung and BAL eosinophilia in a dose-dependent fashion at and above 10 \u00b5g per guinea pig. Treatment with either an experimentally irrelevant, isotype-matched antibody from GL113 cells or with heat-denatured IL-5 antibody was without effect. These studies demonstrate the importance of IL-5 to pulmonary eosinophilia in challenged, allergic guinea pigs.<\/jats:p>","DOI":"10.1164\/ajrccm\/146.1.263","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:36:48Z","timestamp":1365097008000},"page":"263-265","source":"Crossref","is-referenced-by-count":101,"title":["Interleukin-5 Modulates Eosinophil Accumulation in Allergic Guinea Pig Lung"],"prefix":"10.1093","volume":"146","author":[{"given":"A. R.","family":"Gulbenkian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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