{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:40:51Z","timestamp":1774921251821,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In vivo production of thromboxane (TX) A2 and the cysteinyl-containing leukotrienes (LT) C4, D4, and E4 in correlation to airway responses was studied. Bronchial provocation with specific allergen in atopic asthmatics was followed by a significant increase in urinary concentration of immunoreactive LTE4 (34 \u00b1 6 before versus 56 \u00b1 7 ng\/mmol creatinine after allergen challenge; n = 5) and 11-dehydro-TXB2 (164 \u00b1 29 versus 238 \u00b1 25 ng\/mmol creatlnine). In the presence of the leukotriene-antagonist ICI-204,219, which significantly increased the PD20 for allergen, the increment in urinary excretion of LTE4 was even higher (60 \u00b1 8 versus 288 \u00b1 128 ng\/mmol creatlnine; n = 5). In contrast, provocation with histamine (n = 5) did not provoke release of leukotrienes or thromboxane, nor was inhalation of LTD4 (n = 7) associated with increased urinary concentration of 11-dehydro-TXB2. Furthermore, bronchoconstriction induced by inhalation of lysine-aspirin in aspirin-sensitive asthmatics (n = 4) was followed by increased levels of LTE4 in the urine, whereas the levels of 11-dehydro-TXB2 remained the same. Finally, the basal levels of LTE4 in the urine of nine aspirin-sensitive asthmatics were elevated as compared with 15 other asthmatics (112 \u00b1 54 versus 38 \u00b1 20 ng\/mmol creatinine; p &amp;lt; 0.001). The findings support that the cystelnyl-leukotrienes are potential mediators of allergen-induced asthma and that the release of LTE4 and 11-dehydro-TXB2 into the urine appeared to be a direct and dose-dependent effect of the antigen-antibody reaction. Moreover, the findings in aspirin-sensitive asthmatics indicate that cysteinyl-leukotrienes may be of particular importance in the pathogenesis of aspirin-asthma.<\/jats:p>","DOI":"10.1164\/ajrccm\/146.1.96","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:36:48Z","timestamp":1365097008000},"page":"96-103","source":"Crossref","is-referenced-by-count":236,"title":["Urinary Excretion of Leukotriene E4 and 11-dehydro-Thromboxane B2 in Response to Bronchial Provocations with Allergen, Aspirin, Leukotriene D4, and Histamine in Asthmatics"],"prefix":"10.1093","volume":"146","author":[{"given":"Maria","family":"Kumlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbro","family":"Dahl\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thure","family":"Bj\u00f6rck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Zetterstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Granstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven-Erik","family":"Dahl\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,7,1]]},"reference":[{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07289.x"},{"key":"p_22","first-page":"584","year":"1989","journal-title":"Lancet"},{"key":"p_30","first-page":"75","volume":"3","year":"1990","journal-title":"Eicosanoids"},{"key":"p_42","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90277-V"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1975.tb02775.x"},{"key":"p_63","first-page":"609","volume":"123","year":"1981","journal-title":"Rev Respir Dis"},{"key":"p_67","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1152\/jappl.1989.66.4.1685","volume":"66","year":"1989","journal-title":"J Appl Physiol"},{"key":"p_79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1982.tb09295.x"},{"key":"p_84","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0022-3565(25)33174-5","volume":"222","year":"1982","journal-title":"Exp Ther"},{"key":"p_90","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0022-3565(25)23915-5","volume":"239","year":"1986","journal-title":"Exp Ther"},{"key":"p_95","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90232-1"},{"key":"p_104","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90955-7"},{"key":"p_173","doi-asserted-by":"publisher","DOI":"10.1159\/000233762"},{"key":"p_181","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.1.148"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/1\/96\/67642135\/ajrccm_146_1_96.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/1\/96\/67642135\/ajrccm_146_1_96.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:12:33Z","timestamp":1774858353000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/146\/1\/96\/8556889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1992,7,1]]},"published-print":{"date-parts":[[1992,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/146.1.96","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1992,7]]},"published":{"date-parts":[[1992,7,1]]}}}