{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:27:22Z","timestamp":1775204842973,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1992,8,1]],"date-time":"1992-08-01T00:00:00Z","timestamp":712627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The management of patients with unilateral pneumonia and severe hypoxemia often represents a therapeutic challenge. Mechanical ventilation with the diseased lung uppermost may improve gas exchange, but it is not devoid of adverse effects. No hemodynamic measurements have been reported in patients ventilated in this manner; therefore, whether or not the improvement in PaO2 is counterbalanced by hemodynamic deterioration remains unknown. Almitrine bismesylate is a drug that seems able to improve gas exchange in patients with chronic obstructive pulmonary disease or the adult respiratory distress syndrome. The increase in PaO2 after its administration has been attributed to an improvement in ventilation-perfusion relationships. Its use has never been reported during unilateral pneumonia with severe hypoxemia. We therefore compared its effects with those of lateral position in eight consecutive mechanically ventilated patients with unilateral pneumonia. Blood gas and hemodynamic measurements were performed both at maintenance Fi \u00a0O2 and at an Fi \u00a0O2 of 1.0. Almitrine (1 mg\/kg over 1 h) had no effect on PaO2 under either Fi \u00a0O2 condition. Cardiac output remained unchanged, but mean pulmonary artery pressure increased from 22.5 \u00b1 1.2 to 26.5 \u00b1 1.3 mm Hg (p &amp;lt; 0.02). By contrast, lateral position had striking effects on PaO2, which increased from 100 \u00b1 14 mm Hg in supine position to 156 \u00b1 23 mm Hg (p &amp;lt; 0.01) when the abnormal lung was placed uppermost at maintenance Fi \u00a0O2 and from 207 \u00b1 21 (supine) to 300 \u00b1 28 mm Hg (lateral) (p &amp;lt; 0.01) at Fi \u00a0O21.0. Arterial and mixed venous oxygen content were also increased (from 14.0 \u00b1 0.64 to 14.6 \u00b1 0.74 ml% [p &amp;lt; 0.01] and from 9.87 \u00b1 0.69 to 10.53 \u00b1 0.72 ml% [p &amp;lt; 0.05], respectively). No significant change in hemodynamic parameters was observed. In conclusion, almitrine had no beneficial effects on either gas exchange or hemodynamics, whereas lateral positioning markedly improved gas exchange without inducing any deleterious hemodynamic effects, thus potentially allowing a reduction in Fi \u00a0O2.<\/jats:p>","DOI":"10.1164\/ajrccm\/146.2.295","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:35:30Z","timestamp":1365096930000},"page":"295-299","source":"Crossref","is-referenced-by-count":34,"title":["A Comparative Study of the Effects of Almitrine Bismesylate and Lateral Position during Unilateral Bacterial Pneumonia with Severe Hypoxemia"],"prefix":"10.1093","volume":"146","author":[{"given":"Didier","family":"Dreyfuss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Djedaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Lanore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Mier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Froidevaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Coste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,8,1]]},"reference":[{"key":"p_9","first-page":"457","volume":"112","year":"1975","journal-title":"Dis"},{"key":"p_22","first-page":"1159","volume":"137","year":"1988","journal-title":"Dis"},{"key":"p_26","first-page":"49","volume":"110","year":"1974","journal-title":"Respir Dis"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1007\/BF01702625"},{"key":"p_34","first-page":"523","volume":"304","author":"Engl","year":"1981","journal-title":"Med"},{"key":"p_41","doi-asserted-by":"publisher","DOI":"10.1378\/chest.91.1.75"},{"key":"p_57","doi-asserted-by":"publisher","DOI":"10.1378\/chest.97.3.706"},{"key":"p_61","first-page":"351","volume":"1","year":"1987","journal-title":"Lancet"},{"key":"p_63","doi-asserted-by":"publisher","DOI":"10.1378\/chest.83.3.528"},{"key":"p_72","doi-asserted-by":"publisher","DOI":"10.1378\/chest.89.2.174"},{"key":"p_88","doi-asserted-by":"publisher","DOI":"10.1136\/thx.44.4.247"},{"key":"p_91","first-page":"741","volume":"2","year":"1983","journal-title":"Lancet"},{"key":"p_96","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1164\/arrd.1986.134.5.910","volume":"134","year":"1986","journal-title":"Respir Dis"},{"key":"p_100","first-page":"288","volume":"128","year":"1983","journal-title":"Respir Dis"},{"key":"p_109","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1164\/ajrccm\/142.4.789","volume":"142","year":"1990","journal-title":"Respir Dis"},{"key":"p_131","first-page":"2","volume":"142","year":"1990","journal-title":"Dis"},{"key":"p_133","first-page":"537","volume":"304","year":"1981","journal-title":"Med"},{"key":"p_135","doi-asserted-by":"publisher","DOI":"10.1378\/chest.87.1.2"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/2\/295\/67755812\/ajrccm_146_2_295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/2\/295\/67755812\/ajrccm_146_2_295.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:30:22Z","timestamp":1775197822000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/146\/2\/295\/8556911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8,1]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1992,8,1]]},"published-print":{"date-parts":[[1992,8,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/146.2.295","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1992,8]]},"published":{"date-parts":[[1992,8,1]]}}}