{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:26:31Z","timestamp":1775204791506,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Collagen deposition is a prime determinant of clinical course in idiopathic pulmonary fibrosis (IPF). Identification of a marker of connective tissue metabolism would significantly enhance the ability to stage the disease and monitor the course of these patients. Prior studies of IPF have Indicated that N-terminal Type III procollagen peptide (N-PIIIP) levels in blood and bronchoalveolar lavage BAL fluid are elevated. We hypothesized that elevated levels of procollagen peptides are a marker of enhanced collagen deposition, which is associated with interstitial fibrosis characterizing active disease. The purpose of the present study was to explore the relationship between N-PIIIP recovery and physiologic parameters of lung function. N-PIIIP levels in sera and bronchoalveolar lavage (BAL) from 24 patients with IPF and 29 volunteers were measured by radio-immunoassay. The extent of disease in IPF was assessed by clinical history, physical examination, chest radiograph, pulmonary physiology evaluation, and confirmatory open-lung biopsy. The severity of disease was graded using a previously described clinical, radiologic, and physiologic (CRP) scoring system. N-PIIIP normalized to albumin was higher in BAL than in serum for both volunteers (1.6-fold; p &amp;lt; 0.05) and IPF patients (24-fold; p &amp;lt; 0.05), consistent with local pulmonary production. BAL N-PIIIP was significantly elevated in IPF patients, whether expressed as concentration (healthy volunteer 0.11 \u00b1 0.06 ng\/ml; IPF, 5.0 \u00b1 14.4; mean \u00b1 SD; p &amp;lt; 0.05) or normalized to albumin (healthy volunteer, 2.8 \u00b1 1.2; IPF, 73 \u00b1 106; p &amp;lt; 0.05). In the IPF group, the alveolar arterial oxygen gradient during exercise in IPF patients correlated positively with BAL and N-PIIIP\/ml (rho = 0.70; p &amp;lt; 0.001) and N-PIIIP\/ml albumin (rho = 0.76; p &amp;lt; 0.001). The CRP score was correlated with the serum N-PIIIP concentration (rho = 0.48; p &amp;lt; 0.04) and serum N-PIIIP normalized to albumin (rho = 0.60; p &amp;lt; 0.01). These findings suggest that measurements of N-PIIIP levels may be useful in assessing disease activity and reflect the ongoing collagen production that characterizes progressive IPF.<\/jats:p>","DOI":"10.1164\/ajrccm\/146.3.701","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:36:54Z","timestamp":1365097014000},"page":"701-706","source":"Crossref","is-referenced-by-count":39,"title":["Serum and Bronchoalveolar Lavage of N-Terminal Type III Procollagen Peptides in Idiopathic Pulmonary Fibrosis"],"prefix":"10.1093","volume":"146","author":[{"given":"Robert B.","family":"Low","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Giancola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Talmadge E.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Chapitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Vacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald S.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"p_13","first-page":"139","year":"1988","journal-title":"Philadelphia: B. 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