{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:20:29Z","timestamp":1776140429506,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To Investigate the development of a reduced Dl \u00a0CO in patients with HIV-related disease, we studied 474 HIV-seropositive patients and performed serial lung function measurements over 18 months. The mean values of Dl \u00a0CO at presentation were lower in patients with more advanced HIV disease compared with asymptomatic HIV-seropositive patients (Dl \u00a0CO 88% of predicted). When compared with the Dl \u00a0CO in asymptomatic HIV-seropositlve patients, the Dl \u00a0CO had reduced values in patients with persistent generalized lymphadenopathy (PGL) (82% of predicted, p &amp;lt; 0.05), acquired deficiency syndrome-related complex (ARC) (73% predicted, p &amp;lt; 0.001), nonpulmonary Kaposi's sarcoma (KS) (72% of predicted, p &amp;lt; 0.001), nonpulmonary complications of AIDS excluding KS (73% of predicted, p &amp;lt; 0.001), pulmonary KS (63% of predicted, p &amp;lt; 0.001), pulmonary mycobacterial infection (68% of predicted, p &amp;lt; 0.05), pyogenic infection (70%, p &amp;lt; 0.05), acute Pneumocystis carinii pneumonia (PCP; 49%, p &amp;lt; 0.001), and following recovery from PCP (71%, p &amp;lt; 0.001). Serial lung function measurements over 18 months revealed no change in Dl \u00a0CO within any patient group, and in particular there was no tendency for a gradual decline. Clinical deterioration due to the development of PCP was associated with a reduction In Dl \u00a0CO. Conversely, in patients recovering from PCP, there was a partial improvement in Dl \u00a0CO over 3 months. Zidovudine (AZT) use did not affect Dl \u00a0CO within any diagnostic group or the recovery in Dl \u00a0CO following PCP. However, cigarette smoking was associated with further reductions in Dl \u00a0CO in all patient groups and with an impaired recovery of Dl \u00a0CO following acute PCP. This study confirmed that Dl \u00a0CO was reduced in patients with pulmonary and nonpulmonary HIV-related complications. There was no evidence of an insidious decline in Dl \u00a0CO or of a beneficial effect of zidovudine.<\/jats:p>","DOI":"10.1164\/ajrccm\/146.3.745","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:36:54Z","timestamp":1365097014000},"page":"745-751","source":"Crossref","is-referenced-by-count":57,"title":["Pulmonary Function in Human Immunodeficiency Virus Infection: A Prospective 18-Month Study of Serial Lung Function in 474 Patients"],"prefix":"10.1093","volume":"146","author":[{"given":"D. M.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Pinching","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R. W.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Veale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.6.436"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199011000-00012"},{"key":"p_23","first-page":"334","volume":"35","year":"1986","journal-title":"MMWR"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6501.1012"},{"key":"p_38","first-page":"161","volume":"124","year":"1981","journal-title":"Rev Respir Dis"},{"key":"p_47","first-page":"443","volume":"137","year":"1988","journal-title":"Dis"},{"key":"p_60","doi-asserted-by":"publisher","DOI":"10.1378\/chest.97.5.1066"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/3\/745\/67755411\/ajrccm_146_3_745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/3\/745\/67755411\/ajrccm_146_3_745.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:27:11Z","timestamp":1775197631000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/146\/3\/745\/8556970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,1]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1992,9,1]]},"published-print":{"date-parts":[[1992,9,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/146.3.745","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1992,9]]},"published":{"date-parts":[[1992,9,1]]}}}