{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:26:33Z","timestamp":1775204793714,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The cerebrospinal fluid (CSF) concentrations of thyrotropin-releasing hormone (TRH), substance P (SP), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 15 consecutive patients with the sleep apnea syndrome (SAS) and in healthy control subjects. Second measurements were performed 6 months after surgical treatment in 10 of the patients. The mean (\u00b1 SD) concentration of TRH-like immunoreactive material (TRH-LIM) (pg\/ml) did not differ significantly between patients with SAS (8.1 \u00b1 2.8) and control subjects (7.5 \u00b1 2.2). However, postoperatively, this concentration was increased in the six clinically cured patients with SAS, from 6.9 \u00b1 2.7 to 9.4 \u00b1 1.6 (p &amp;lt; 0.03). Substance P-like immunoreactive material (SP-LIM) was higher in untreated patients with SAS than in control subjects: 19.2 \u00b1 6.7 versus 14.4 \u00b1 4.2 fmol\/ml (p &amp;lt; 0.02), and the level remained high after operation in the group treated surgically. The HVA, 5-HIAA, and MHPG concentrations were similar in patients with SAS and control subjects, and no consistent changes were found postoperatively. The CSF deviations in TRH-LIM and SP-LIM concentrations in the patients may reflect a primary central nervous system defect or they may be secondary to intermittent nocturnal hypoxia, progressive hypercapnia, and\/or sleep fragmentation. In this sense, both these systems may be markers of SAS-SP as a \u201ctrait\u201d marker and TRH as an indicator of the current state.<\/jats:p>","DOI":"10.1164\/ajrccm\/146.3.784","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:36:54Z","timestamp":1365097014000},"page":"784-786","source":"Crossref","is-referenced-by-count":11,"title":["Substance P, Thyrotropin-releasing Hormone, and Monoamine Metabolites in Cerebrospinal Fluid in Sleep Apnea Patients"],"prefix":"10.1093","volume":"146","author":[{"given":"Thorarinn","family":"Gislason","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hedner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Terenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garth","family":"Bisette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Nemeroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"p_3","first-page":"347","volume":"26","year":"1980","journal-title":"Med"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1987.tb08113.x"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.2.250"},{"key":"p_38","first-page":"45","volume":"114","year":"1988","journal-title":"Head Neck Surg"},{"key":"p_41","first-page":"20","volume":"16","year":"1967","journal-title":"Ann Med"},{"key":"p_48","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1176\/ajp.145.12.1526","volume":"145","year":"1988","journal-title":"Am J Psych"},{"key":"p_62","first-page":"693","volume":"68","year":"1989","journal-title":"J Appl Physiol"},{"key":"p_74","first-page":"325","volume":"345","author":"Bio I","year":"1990","journal-title":"Res"},{"key":"p_87","first-page":"43","volume":"2","year":"1978","journal-title":"Sleeping"},{"key":"p_91","doi-asserted-by":"publisher","DOI":"10.1016\/0031-6989(87)90094-4"},{"key":"p_93","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.637"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/3\/784\/67755325\/ajrccm_146_3_784.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/146\/3\/784\/67755325\/ajrccm_146_3_784.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:27:26Z","timestamp":1775197646000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/146\/3\/784\/8556987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,1]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1992,9,1]]},"published-print":{"date-parts":[[1992,9,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/146.3.784","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1992,9]]},"published":{"date-parts":[[1992,9,1]]}}}