{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:29:15Z","timestamp":1775204955996,"version":"3.50.1"},"reference-count":3,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A study was undertaken to evaluate the usefulness of a dye-scattering method for the analysis of bronchial lesions. After methylene blue was introduced through a cannula, the bronchial staining intensities seen by bronchofibroscopy were later compared with the histologic findings in 74 biopsied specimens of lesions taken from 20 patients with lung cancer and from 6 patients with bronchiectasis, 2 with a rheumatoid lung, and 2 with sarcoidosis. It was found that 86% (25 of 29) of the specimens that stained positively were malignant. Further, 4 specimens that manifested a false positive response to staining were either too small to be inspected histologically or showed necrosis. Of 27 specimens that were negative to staining, 89% (24 of 27) were revealed to be nonmalignant lesions. In this latter group the response of 3 specimens was false negative on histologic inspection, 2 showing cancer cells without surface infiltration. We thus conclude that this dye-scattering method is of great use in enabling the differentiation of nonmalignant mucosa from neoplastic lesions and the preoperative determination of the stage of a tumor.<\/jats:p>","DOI":"10.1164\/ajrccm\/147.1.208","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T01:02:28Z","timestamp":1311296548000},"page":"208-210","source":"Crossref","is-referenced-by-count":1,"title":["A Bronchofibroscopic Analysis of the Bronchial Mucosa Using a Dye-scattering Method for the Detection of Bronchial Lesions"],"prefix":"10.1093","volume":"147","author":[{"given":"Kingo","family":"Chida","sequence":"first","affiliation":[{"name":"Second Division, Department of Internal Medicine, and the Department of Hospital Pathology, Hamamatsu University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, and the Department of Hospital Pathology, Hamamatsu University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, and the Department of Hospital Pathology, Hamamatsu University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, and the Department of Hospital Pathology, Hamamatsu University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, and the Department of Hospital Pathology, Hamamatsu University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Shichi","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, and the Department of Hospital Pathology, Hamamatsu University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Nakano","sequence":"additional","affiliation":[{"name":"Second Division, Department of Internal Medicine, and the Department of Hospital Pathology, Hamamatsu University School of Medicine, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,1,1]]},"reference":[{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900110310"},{"key":"p_3","first-page":"266","volume":"128","author":"Baughman RP","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(89)80058-7"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/147\/1\/208\/67756527\/ajrccm_147_1_208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/147\/1\/208\/67756527\/ajrccm_147_1_208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:37:08Z","timestamp":1775198228000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/147\/1\/208\/8556381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1,1]]},"references-count":3,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1993,1,1]]},"published-print":{"date-parts":[[1993,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/147.1.208","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1993,1]]},"published":{"date-parts":[[1993,1,1]]}}}