{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:31:03Z","timestamp":1775205063872,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The in vivo function of surfactants reconstituted using natural surfactant lipid and protein constituents was evaluated in 27-day-gestation preterm rabbits. The animals were treated with protein-free surfactant lipids (LH-20), LH-20 + 5% SP-A, LH-20 + 1% SP-B, LH-20 + 1% SP-C, LH-20 + 5% SP-A + 1% SP-B + 1% SP-C (SP-ABC), natural sheep surfactant, or 4 ml\/kg 0.45% NaCl (control) and then ventilated with tidal volumes of 8 ml\/kg and 3 cm H2O positive end-expiratory pressure (PEEP). Ventilatory pressures (peak pressures minus PEEP) and dynamic compliances of the LH-20 + SP-C rabbits were greater (p &amp;lt; 0.01) than those of control, LH-20, and LH-20 + SP-A groups but lower (p &amp;lt; 0.05) than those in the LH-20 + SP-B, LH-20 + SP-ABC, and sheep surfactant groups. Recoveries of intravascular labeled albumin in the lungs were comparable in the LH-20 + SP-B, LH-20 + SP-C, LH-20 + SP-ABC, and sheep surfactant groups and less (p &amp;lt; 0.01) than in LH-20 + SP-A rabbits, which had lower (p &amp;lt; 0.05) recoveries than did the control and LH-20 groups. The postventilation pressure-volume curves for LH-20 + SP-B and LH-20 + SP-ABC rabbits had significantly lower opening pressures, larger maximal lung volumes, and larger retained volumes on deflation relative to the LH-20 + SP-C, LH-20, and control groups. The effects of ventilation style on the responses were assessed by ventilating another group of similarly treated rabbits with tidal volumes of 10 ml\/kg and zero cm H2O PEER Without PEEP, only sheep surfactant demonstrated effective responses. In vivo function of reconstituted surfactants containing SP-B was comparable to sheep surfactant, but, unlike natural surfactant, the activity was dependent upon a ventilation style using PEEP.<\/jats:p>","DOI":"10.1164\/ajrccm\/147.3.669","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:41:07Z","timestamp":1365097267000},"page":"669-676","source":"Crossref","is-referenced-by-count":66,"title":["Treatment Responses to Surfactants Containing Natural Surfactant Proteins in Preterm Rabbits"],"prefix":"10.1093","volume":"147","author":[{"given":"Evelyn D.","family":"Rider","sequence":"first","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California, and University of Cincinnati, Department of Pulmonary Biology, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machiko","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California, and University of Cincinnati, Department of Pulmonary Biology, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Whitsett","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California, and University of Cincinnati, Department of Pulmonary Biology, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Hull","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California, and University of Cincinnati, Department of Pulmonary Biology, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darryl","family":"Absolom","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California, and University of Cincinnati, Department of Pulmonary Biology, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Jobe","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, California, and University of Cincinnati, Department of Pulmonary Biology, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,3,1]]},"reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1164\/ajrccm\/142.4.754","volume":"142","author":"Vamada T","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2730249","volume":"173","author":"Weaver TE","year":"1991","journal-title":"Biochem 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