{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:36:23Z","timestamp":1775205383923,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated the efficacy of intratracheal perfluorocarbon (PFC) administration combined with mechanical ventilation to support gas exchange in adult animals with acute respiratory failure. These were compared with a similar group of animals treated with continuous positive-pressure ventilation (CPPV) with respect to respiratory parameters and postmortem lung histology. After lung lavage with saline, 18 adult rabbits were divided into three groups (n = 6 per group). All groups received conventional CPPV. Additionally, one group received intratracheal PFC administration at a volume of 18 ml\/kg (corresponding to functional residual capacity) (PFC group); another received 18 ml\/kg of saline administration (saline group), and the last had no further treatment (CPPV group). All groups were ventilated for 3 h using 100% oxygen, with the same ventilator settings of tidal volume of 12 ml\/kg, respiratory frequency of 30\/min, and positive end-expiratory pressure of 6 cm H2O. In the PFC group, PaO2 increased from 67.2 \u00b1 11.4 to 424.2 \u00b1 14 mm Hg and remained stable for 3 h with well-preserved PaCO2 values. Only in the PFC group were significant decreases in airway pressures and increase in respiratory system compliance seen. In the CPPV group, PaO2 stayed around 60 mm Hg and PaCO2 gradually increased. PFC treatment with conventional mechanical ventilation in acute respiratory failure proved to be a successful supportive technique to improve gas exchange at low inflation pressures.<\/jats:p>","DOI":"10.1164\/ajrccm\/148.3.785","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T16:21:57Z","timestamp":1312388517000},"page":"785-792","source":"Crossref","is-referenced-by-count":134,"title":["Comparison of Ventilatory Support with Intratracheal Perfluorocarbon Administration and Conventional Mechanical Ventilation in Animals with Acute Respiratory Failure"],"prefix":"10.1093","volume":"148","author":[{"given":"Ahmet S.","family":"T\u00fct\u00fcnc\u00fc","sequence":"first","affiliation":[{"name":"Departments of Anesthesiology, Erasmus University Rotterdam, the Netherlands, and Medical Faculty, University of Istanbul, Turkey, and the Department of Medical Research, Alliance Pharmaceutical Corporation, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Simon","family":"Faithfull","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Erasmus University Rotterdam, the Netherlands, and Medical Faculty, University of Istanbul, Turkey, and the Department of Medical Research, Alliance Pharmaceutical Corporation, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Lachmann","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology, Erasmus University Rotterdam, the Netherlands, and Medical Faculty, University of Istanbul, Turkey, and the Department of Medical Research, Alliance Pharmaceutical Corporation, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1993,9,1]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.49.7.505"},{"key":"p_2","first-page":"141","author":"Lachmann B.","year":"1982","journal-title":"Hague: Martinus Nijhoff"},{"key":"p_3","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1164\/arrd.1987.135.6.1363","volume":"135","author":"Froese AB","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380070087025"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01735174"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199110000-00004"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198308000-00016"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197604000-00005"},{"key":"p_9","first-page":"49","volume":"19","author":"Shaffer TH","year":"1983","journal-title":"Pediatr Res"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198304000-00017"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82457-6"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199105000-00019"},{"key":"p_13","first-page":"729","volume":"11","author":"Jonson B","year":"1975","journal-title":"Bull Physiopathol Respir"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/52.5.491"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1980.tb01541.x"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198211000-00005"},{"key":"p_17","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1152\/jappl.1984.57.4.995","volume":"57","author":"Kobayashi T","year":"1984","journal-title":"J Appl Physiol"},{"key":"p_18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/jappl.1983.55.1.131","volume":"55","author":"Hamilton PP","year":"1983","journal-title":"J Appl Physiol"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709882"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(90)90386-N"},{"key":"p_21","first-page":"312","volume":"135","author":"Kolobow T.","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"p_22","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1164\/ajrccm\/137.5.1159","volume":"137","author":"Dreyfuss D","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"p_23","doi-asserted-by":"publisher","DOI":"10.1007\/BF01705155"},{"key":"p_24","first-page":"83","volume":"1565","author":"Clements JA.","year":"1965","journal-title":"Respiration. Washington, DC: American Physiological Society"},{"key":"p_25","first-page":"1","volume":"13","author":"Wolfson MR","year":"1990","journal-title":"J Dev Physiol"},{"key":"p_26","first-page":"647","volume":"43","author":"Forman DL","year":"1984","journal-title":"Fed Proc"},{"key":"p_27","doi-asserted-by":"publisher","DOI":"10.1159\/000240884"},{"key":"p_28","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1152\/jappl.1979.47.5.1051","volume":"47","author":"Lowe CA","year":"1979","journal-title":"J Appl Physiol"},{"key":"p_29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1152\/jappl.1986.60.1.154","volume":"60","author":"Lowe CA","year":"1986","journal-title":"J Appl Physiol"},{"key":"p_30","first-page":"229","volume":"8","author":"Lowe CA","year":"1981","journal-title":"Undersea Biomed Res"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199102000-00019"},{"key":"p_33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1148\/radiology.170.1.2909093","volume":"170","author":"Bruneton IN","year":"1989","journal-title":"Radiology"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/42.8.669"},{"key":"p_35","first-page":"425","volume":"85","author":"Manny J","year":"1979","journal-title":"Surgery"},{"key":"p_36","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199102000-00019"}],"container-title":["American Review of Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/148\/3\/785\/67757590\/ajrccm_148_3_785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/148\/3\/785\/67757590\/ajrccm_148_3_785.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:54:10Z","timestamp":1775199250000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/148\/3\/785\/8560649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9,1]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1993,9,1]]},"published-print":{"date-parts":[[1993,9,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/148.3.785","relation":{},"ISSN":["0003-0805"],"issn-type":[{"value":"0003-0805","type":"print"}],"subject":[],"published-other":{"date-parts":[[1993,9]]},"published":{"date-parts":[[1993,9,1]]}}}