{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:18:37Z","timestamp":1791595117348,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1995,4,1]],"date-time":"1995-04-01T00:00:00Z","timestamp":796694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin-8 (IL-8) is a potent neutrophil chemoattractant and activator. Pneumocystis carinii pneumonia is associated with an accumulation of neutrophils in bronchoalveolar lavage (BAL) fluid. Thus, we hypothesized that IL-8 is involved in the pathogenesis of P. carinii pneumonia. BAL fluid and serum were prospectively collected in 76 consecutive HIV-infected patients with a primary episode of P. carinii pneumonia, as well as in 10 healthy control subjects. Patients were found to have elevated levels of IL-8 in BAL fluid compared with control subjects (p &amp;lt; 0.01). Nine patients died during the course of P. carinii pneumonia. Comparing survivors with nonsurvivors, the median IL-8 level in BAL fluid was 127 (0 to 3,900) versus 584 (127 to 6,100) pg\/ml (p &amp;lt; 0.05). Furthermore, patients with levels of IL-8 in BAL fluid greater than 90 pg\/ml (i.e., greater than control subjects) had significantly worse vital prognosis (log rank test, p &amp;lt; 0.05). Thirteen percent required mechanical ventilation (MV). Patients requiring MV had a median IL-8 level of 396 (25 to 6,100) versus 129 (0 to 3,900) pg\/ml for patients not requiring MV (p &amp;lt; 0.05). In conclusion: i) IL-8 in BAL fluid correlates to the clinical severity of the pneumonia, and ii) is a predictor of mortality and severe respiratory compromise.<\/jats:p>","DOI":"10.1164\/ajrccm\/151.4.1058","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:40Z","timestamp":1365098020000},"page":"1058-1062","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of Interleukin-8 in AIDS-Associated\n                    <i>Pneumocystis Carinii<\/i>\n                    Pneumonia"],"prefix":"10.1093","volume":"151","author":[{"given":"Thomas L.","family":"Benfield","sequence":"first","affiliation":[{"name":"Departments of Infectious Diseases and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Vestbo","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette","family":"Junge","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thyge L.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mette B\u00e6k","family":"Jensen","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens D.","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,4,1]]},"container-title":["American Journal of Respiratory and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/4\/1058\/67680292\/ajrccm_151_4_1058a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/4\/1058\/67680292\/ajrccm_151_4_1058a.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:00:35Z","timestamp":1774936835000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/4\/1058\/8565859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1995,4,1]]},"published-print":{"date-parts":[[1995,4,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm\/151.4.1058","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,4]]},"published":{"date-parts":[[1995,4,1]]}}}