{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:30:55Z","timestamp":1774679455829,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1994,2,1]],"date-time":"1994-02-01T00:00:00Z","timestamp":760060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The current study was done to look at the long-term enhancing effect of a single viral infection on repeated Saccharopolyspora rectivirgula (SR) antigenic challenges in mice and at inflammatory cytokines in this enhancement. Four groups of C57BI\/6 mice were studied: Group 1 received intranasal instillations of saline, 3 days per week; Group 2, intranasal instillations of saline plus one intranasal instillation of 80 hemagglutination units (HAU) of Sendai virus after 3 wk of saline; Group 3, instillations of SR, 3 days per week; and Group 4, instillations of SR, 3 days per week, plus one instillation of Sendai virus after 3 wk of SR. Bronchoalveolar lavages (BAL) were performed 15 and 30 wk after the virus inoculation in the appropriate groups. Each time, a two- to threefold increase in BAL cell counts was obtained from virus-infected animals challenged with SR compared with animals that received the SR alone. Animals infected with virus only showed values similar to those of control animals. A higher percentage of large foamy multinucleated cells were found in the BAL from the SR+Sendai group than the SR alone group (7.92 +\/- 0.730% compared with 1.8 +\/- 0.296%). These cells were not seen in the other groups. BAL levels of TNF-alpha and IL-1 alpha at 15 wk were much higher in SR+Sendai-treated (1,439 +\/- 268 and 96 +\/- 9 pg\/ml, respectively) than SR alone-treated animals (361 +\/- 100 and 23 +\/- 4 pg\/ml). BAL fluid of control animals and Sendai alone animals contained 64 +\/- 24 and 65 +\/- 15 pg\/ml of TNF-alpha, but no IL-1 alpha was detected.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1164\/ajrccm.149.2.8306051","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:51:43Z","timestamp":1365097903000},"page":"490-494","source":"Crossref","is-referenced-by-count":23,"title":["Long-Term Viral Enhancement of Lung Response to Saccharopolyspora Rectivirgula"],"prefix":"10.1093","volume":"149","author":[{"given":"Y","family":"Cormier","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche, Centre de Pneumologie, H\u00f4pital Laval, Universit\u00e9 Laval, Sainte-Foy, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche, Centre de Pneumologie, H\u00f4pital Laval, Universit\u00e9 Laval, Sainte-Foy, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fournier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche, Centre de Pneumologie, H\u00f4pital Laval, Universit\u00e9 Laval, Sainte-Foy, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Isra\u00ebl-Assayag","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche, Centre de Pneumologie, H\u00f4pital Laval, Universit\u00e9 Laval, Sainte-Foy, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1994,2,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/149\/2\/490\/67608364\/ajrccm_149_2_490.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/149\/2\/490\/67608364\/ajrccm_149_2_490.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:44:26Z","timestamp":1774673066000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/149\/2\/490\/8551632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1994,2,1]]},"published-print":{"date-parts":[[1994,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.149.2.8306051","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1994,2]]},"published":{"date-parts":[[1994,2,1]]}}}