{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:04:40Z","timestamp":1791896680882,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A previous uncontrolled study suggested that nasal continuous positive airway positive airway pressure (NCPAP) may improve left ventricular ejection fraction (LVEF) in patients with congestive heart failure (CHF) and Cheyne-Stokes respiration with central sleep apnea (CSR-CSA). In order to more critically evaluate the effects of NCPAP on cardiac function, we undertook a randomized, controlled trial of NCPAP in 29 patients with heart failure and CSR-CSA over a 3-mo period, with LVEF as the primary outcome measure. Patients with CHF and associated CSR-CSA who were receiving optimal medical therapy were randomly assigned to a control group (n = 15) or a group receiving nightly NCPAP (n = 14). Twelve patients in each group completed the study. There was a greater improvement of LVEF in the NCPAP group than in the control group during the study (mean +\/- SEM = 7.7 +\/- 2.5 versus - 0.5 +\/- 1.5%, p = 0.019). In addition, there was a significantly greater reduction in the number of apneas and hypopneas (-28.5 +\/- 3.9 versus -6.1 +\/- 7.0 per hour of sleep, p = 0.012) in the NCPAP group than in the control group. Significantly greater improvements in symptoms of fatigue (5.6 +\/- 1.2 versus 0.8 +\/- 0.7, p = 0.005) and disease mastery (3.6 +\/- 1.1 versus -0.7 +\/- 0.7, p = 0.031) were also observed in the NCPAP group. We conclude that in patients with chronic heart failure and CSR-CSA, nightly administration of NCPAP can attenuate CSR-CSA, improve cardiac function, and alleviate symptoms of heart failure.<\/jats:p>","DOI":"10.1164\/ajrccm.151.1.7812579","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:52:56Z","timestamp":1365097976000},"page":"92-97","source":"Crossref","is-referenced-by-count":257,"title":["Treatment of Congestive Heart Failure and Cheyne-Stokes Respiration during Sleep by Continuous Positive Airway Pressure"],"prefix":"10.1093","volume":"151","author":[{"given":"M T","family":"Naughton","sequence":"first","affiliation":[{"name":"Sleep Research Laboratory, Queen Elizabeth Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P P","family":"Liu","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory, Queen Elizabeth Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Bernard","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory, Queen Elizabeth Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory, Queen Elizabeth Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T D","family":"Bradley","sequence":"additional","affiliation":[{"name":"Sleep Research Laboratory, Queen Elizabeth Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,1,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/1\/92\/67625561\/ajrccm_151_1_92.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/1\/92\/67625561\/ajrccm_151_1_92.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:19:25Z","timestamp":1774685965000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/1\/92\/8553483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1995,1,1]]},"published-print":{"date-parts":[[1995,1,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.151.1.7812579","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,1]]},"published":{"date-parts":[[1995,1,1]]}}}