{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:30:50Z","timestamp":1776987050620,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of the study was to evaluate the effects of blocking the integrins VLA-4 and LFA-1 on allergen-induced airway eosinophilia and responsiveness in Brown-Norway rats. Ovalbumin-sensitized rats were exposed to either aerosols of ovalbumin or saline. Airway responsiveness to methacholine (MCh) was determined 8 and 32 h after challenge. Cellular populations in the lung lavage and lung tissues were determined 32 h after allergen challenge. Total numbers of eosinophils were increased in the lung lavage (25 ml) and the small airways\/parenchyma in the ovalbumin (OA)-challenged rats (4.37 x 10(6) +\/- 0.71 and 15.54 x 10(6) +\/- 1.99, respectively) compared with the saline-challenged rats (0.99 x 10(6) +\/- 0.81 and 4.84 x 10(6) +\/- 2.27; p &amp;lt; 0.05). Animals treated with both anti-VLA-4 and anti-LFA-1 mAbs and with anti-LFA-1 mAb alone had reduced numbers of eosinophils in the lung lavage (0.76 x 10(6) +\/- 0.80 and 0.40 x 10(6) +\/- 1.14, respectively; p &amp;lt; 0.05) and in the small airways\/parenchyma (8.64 x 10(6) +\/- 2.07 and 4.44 x 10(6) +\/- 3.20; p &amp;lt; 0.05). Anti-VLA-4 mAb treatment alone did not alter the eosinophils recovered from the lung. Airway responsiveness to methacholine increased from 8 to 32 h in all ovalbumin-challenged rats, but treatment with anti-VLA-4, anti-LFA-1, or both mAbs prevented the increase in responsiveness. In conclusion, allergen-induced airway hyperresponsiveness is inhibitable by blocking either VLA-4 or LFA-1 integrins and is associated with a lung eosinophilia that is LFA-1 dependent and VLA-4 independent.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1164\/ajrccm.151.3.7881677","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:52:32Z","timestamp":1365097952000},"page":"822-829","source":"Crossref","is-referenced-by-count":2,"title":["Role of VLA-4 and LFA-1 in Allergen-Induced Airway Hyperresponsiveness and Lung Inflammation in the Rat"],"prefix":"10.1093","volume":"151","author":[{"given":"S","family":"Laberge","sequence":"first","affiliation":[{"name":"Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Rabb","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T B","family":"Issekutz","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Martin","sequence":"additional","affiliation":[{"name":"Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,3,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/3\/822\/8553503","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/3\/822\/8553503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:21:02Z","timestamp":1774686062000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/3\/822\/8553503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1995,3,1]]},"published-print":{"date-parts":[[1995,3,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.151.3.7881677","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,3]]},"published":{"date-parts":[[1995,3,1]]}}}