{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:27:57Z","timestamp":1788967677616,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1995,5,1]],"date-time":"1995-05-01T00:00:00Z","timestamp":799286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"Abstract<\/jats:title>\n To determine whether inhaled nitric oxide (NO) affects pulmonary circulation, thereby improving right ventricular (RV) function in adult respiratory distress syndrome (ARDS), we studied 13 patients with both a lung injury severity score of 2.5 or more and a mean pulmonary artery pressure higher than 30 mm Hg. RV function was assessed by a thermodilution technique using a pulmonary artery catheter equipped with a rapid response thermistor before and 15 min after initiation of inhalation of NO (5 ppm). At baseline, stroke volumes were in a normal range (46 +\/- 14 ml\/m2), with a RV dilation (end-diastolic volume = 142 +\/- 36 ml\/m2). Inhaled NO was followed by an improvement in arterial oxygenation (PaO2\/FIO2 = 103 +\/- 47 versus 142 +\/- 63, p &lt; 0.05) and a drop in pulmonary artery pressure (36.1 +\/- 4.5 versus 31.3 +\/- 6.1 mm Hg, p &lt; 0.01); stroke volumes and heart rates did not change. The resulting fall in pulmonary vascular resistance (211 +\/- 43 versus 180 +\/- 59 dyn-s\/cm5, p &lt; 0.05) was associated with an increase in RV, ejection fractions (32 +\/- 5 versus 36 +\/- 6%, p &lt; 0.05), a trend toward decreased RV end-systolic (96 +\/- 25 versus 85 +\/- 19 ml\/m2, NS) and end-diastolic (142 +\/- 36 versus 131 +\/- 27 ml\/m2, NS) volumes, and a decrease in right atrial pressures (10.9 +\/- 2.9 versus 9.6 +\/- 3.2 mm Hg, p &lt; 0.05). No relationship was seen between the improvement in arterial oxygenation and the decrease in pulmonary vascular resistance.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1164\/ajrccm.151.5.7735594","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:07Z","timestamp":1365097987000},"page":"1414-1419","source":"Crossref","is-referenced-by-count":98,"title":["Effect of Inhaled Nitric Oxide on Right Ventricular Function in Adult Respiratory Distress Syndrome"],"prefix":"10.1093","volume":"151","author":[{"given":"L","family":"Fierobe","sequence":"first","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Brunet","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Dhainaut","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Monchi","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Belghith","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Mira","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dall'ava-Santucci","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A T","family":"Dinh-Xuan","sequence":"additional","affiliation":[{"name":"Department of Medical Intensive Care Unit, Cochin Hospital, Cochin-Port-Royal Medical School, Ren\u00e9 Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,5,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/5\/1414\/67625825\/ajrccm_151_5_1414.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/5\/1414\/67625825\/ajrccm_151_5_1414.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:22:32Z","timestamp":1774686152000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/5\/1414\/8553618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1995,5,1]]},"published-print":{"date-parts":[[1995,5,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.151.5.7735594","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,5]]},"published":{"date-parts":[[1995,5,1]]}}}