{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:14:46Z","timestamp":1791346486417,"version":"4.3.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The distribution of tidal volume (VT) and recruitment was investigated by chest computed tomography (CT) in eight sedated-paralyzed patients with the adult respiratory distress syndrome (ARDS). A CT section was obtained in the supine position at 0, 5, 10, 15, and 20 cm H2O positive end-expiratory pressure (PEEP) and at the corresponding inspiratory plateau pressure (21 +\/- 1.8, 26 +\/- 1.4, 31 +\/- 1.8, 38 +\/- 2.1, and 46 +\/- 3.2 cm H2O [mean +\/- SE]), keeping VT constant. Each CT section was divided along its ventral-dorsal height into 10 equally spaced intervals (levels). Vi(insp) and Vi(exp) were defined as the gas volume for level i (i = 1 to 10) at end-inspiration and at end-expiration, respectively. The following variables were computed at each lung level: (1) distribution of CT section tidal volume (VTct), i.e., the fraction of VT that inflates a given lung level; (2) the plateau-induced and PEEP-induced recruitment, i.e., the amount of lung tissue previously collapsed that inflates at plateau pressure and at PEEP, respectively; (3) the reopening-collapsing tissue, i.e., the amount of lung tissue that regains inflation at plateau pressure and collapses at PEEP. With increasing PEEP from 0 to 20 cm H2O, the VTct distribution decreased significantly (p &amp;lt; 0.01) in the upper levels, did not change in the middle levels, and increased significantly (p &amp;lt; 0.01) in the lower levels.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1164\/ajrccm.151.6.7767524","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:26Z","timestamp":1365098006000},"page":"1807-1814","source":"Crossref","is-referenced-by-count":468,"title":["Effects of Positive End-Expiratory Pressure on Regional Distribution of Tidal Volume and Recruitment in Adult Respiratory Distress Syndrome"],"prefix":"10.1093","volume":"151","author":[{"given":"L","family":"Gattinoni","sequence":"first","affiliation":[{"name":"Istituto di Anestesia e Rianimazione, IRCCS Universit\u00e1 degli Studi di Milano, Ospedale Maggiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Pelosi","sequence":"additional","affiliation":[{"name":"Istituto di Anestesia e Rianimazione, IRCCS Universit\u00e1 degli Studi di Milano, Ospedale Maggiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Crotti","sequence":"additional","affiliation":[{"name":"Istituto di Anestesia e Rianimazione, IRCCS Universit\u00e1 degli Studi di Milano, Ospedale Maggiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Valenza","sequence":"additional","affiliation":[{"name":"Istituto di Anestesia e Rianimazione, IRCCS Universit\u00e1 degli Studi di Milano, Ospedale Maggiore, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,6,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/6\/1807\/67625949\/ajrccm_151_6_1807.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/6\/1807\/67625949\/ajrccm_151_6_1807.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:24:15Z","timestamp":1774686255000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/6\/1807\/8553666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1995,6,1]]},"published-print":{"date-parts":[[1995,6,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.151.6.7767524","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,6]]},"published":{"date-parts":[[1995,6,1]]}}}