{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:01:07Z","timestamp":1774688467466,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ofloxacin and ciprofloxacin are potentially useful agents for treating mycobacterial infections. We retrospectively reviewed 7 years' experience with these agents in 103 patients. Ofloxacin was used primarily to treat tuberculosis (TB), dosed to achieve 2-hour postdose serum concentrations of 8-12 micrograms\/ml. Ciprofloxacin was used primarily to treat Mycobacterium avium complex (MAC) infection, dosed to achieve 2-hour post-dose serum concentrations of 4-6 micrograms\/ml. Despite differences in patient characteristics, underlying disease, and concurrent medications, ofloxacin and ciprofloxacin were associated with a similar spectrum and incidence of adverse reactions. Both drugs were generally well tolerated. Adverse effects led to an ofloxacin dosage change in 1 patient (3%) and discontinuation of ofloxacin in 2 patients (6%). Adverse effects led to a ciprofloxacin dosage change in 2 patients (3%) and discontinuation of ciprofloxacin in 5 patients (7%). Ofloxacin and ciprofloxacin appear to be tolerated as well as or better than other \"second-line\" antimycobacterial drugs.<\/jats:p>","DOI":"10.1164\/ajrccm.151.6.7767552","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:26Z","timestamp":1365098006000},"page":"2006-2009","source":"Crossref","is-referenced-by-count":36,"title":["Long-Term Safety of Ofloxacin and Ciprofloxacin in the Treatment of Mycobacterial Infections"],"prefix":"10.1093","volume":"151","author":[{"given":"S E","family":"Berning","sequence":"first","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M D","family":"Iseman","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Peloquin","sequence":"additional","affiliation":[{"name":"Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,6,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/6\/2006\/67626039\/ajrccm_151_6_2006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/151\/6\/2006\/67626039\/ajrccm_151_6_2006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:25:01Z","timestamp":1774686301000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/151\/6\/2006\/8553693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1995,6,1]]},"published-print":{"date-parts":[[1995,6,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.151.6.7767552","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,6]]},"published":{"date-parts":[[1995,6,1]]}}}