{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:24:13Z","timestamp":1793532253967,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We hypothesized that (1) patients with congestive heart failure (CHF) and Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) would have greater nocturnal urinary and daytime plasma norepinephrine concentrations (UNE and PNE, respectively) than those without CSR-CSA because of apneas, hypoxia and arousals from sleep and (2) attenuation of CSR-CSA by nasal continuous positive airway pressure (NCPAP) would reduce UNE and PNE concentrations. Eighteen patients with and 17 without CSR-CSA (Non-CSR-CSA group) were studied. Left ventricular ejection fraction was similar in the two groups, but overnight UNE and awake PNE concentrations were greater in the CSR-CSA group (30.2 +\/- 2.5 nmol\/mmol creatinine and 3.32 +\/- 0.29 nmol\/L) than in the Non-CSR-CSA group (15.8 +\/- 2.1 nmol\/mmol creatinine, p &amp;lt; 0.005, and 2.06 +\/- 0.56 nmol\/L, p &amp;lt; 0.05, respectively). Patients with CSR-CSA were randomized to a control group or to nightly NCPAP for 1 mo. CSR-CSA was attenuated in the NCPAP but not in the control group. The NCPAP group experienced greater reductions in UNE and PNE concentrations (-12.5 +\/- 3.3 nmol\/mmol creatinine and -0.74 +\/- 0.40 nmol\/L) than did the control group (-1.3 +\/- 2.8 nmol\/mmol creatinine, p &amp;lt; 0.025 and 1.16 +\/- 0.66 nmol\/L, p &amp;lt; 0.025, respectively). In conclusion, in patients with CHF, CSR-CSA is associated with elevated sympathoneural activity, which can be reduced by NCPAP.<\/jats:p>","DOI":"10.1164\/ajrccm.152.2.7633695","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:10Z","timestamp":1365097990000},"page":"473-479","source":"Crossref","is-referenced-by-count":375,"title":["Effects of Nasal CPAP on Sympathetic Activity in Patients With Heart Failure and Central Sleep Apnea"],"prefix":"10.1093","volume":"152","author":[{"given":"M T","family":"Naughton","sequence":"first","affiliation":[{"name":"Queen Elizabeth Hospital Sleep Research Laboratory, Department of Medicine, Toronto Hospital, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Benard","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Sleep Research Laboratory, Department of Medicine, Toronto Hospital, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P P","family":"Liu","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Sleep Research Laboratory, Department of Medicine, Toronto Hospital, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Sleep Research Laboratory, Department of Medicine, Toronto Hospital, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Rankin","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Sleep Research Laboratory, Department of Medicine, Toronto Hospital, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T D","family":"Bradley","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Sleep Research Laboratory, Department of Medicine, Toronto Hospital, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,8,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/2\/473\/67626960\/ajrccm_152_2_473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/2\/473\/67626960\/ajrccm_152_2_473.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:40:09Z","timestamp":1774687209000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/152\/2\/473\/8553791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1995,8,1]]},"published-print":{"date-parts":[[1995,8,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.152.2.7633695","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,8]]},"published":{"date-parts":[[1995,8,1]]}}}