{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:08:17Z","timestamp":1774688897519,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1995,8,1]],"date-time":"1995-08-01T00:00:00Z","timestamp":807235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To determine whether pulmonary function test (PFT) results after marrow transplantation were predictive of nonrelapse mortality, a review was made of prospective, nonrandomized PFT results for association with nonrelapse mortality by log-rank test and Cox proportional hazards modeling. The setting was a tertiary referral center. The patients were all marrow recipients who performed PFT between Days 60 and 120 after marrow transplantation between July 1, 1983 and December 31, 1990 (n = 906). At 3 mo after transplantation, the mean values for total lung capacity (TLC) and diffusing capacity decreased, and restrictive ventilatory defects (TLC &amp;lt; 80% of predicted) were noted in 34% of the cohort. Airflow rates (FEV1\/FVC) were unchanged. A restrictive lung defect at 3 mo after transplant or a significant decline (&amp;gt; or = 15%) in TLC from baseline despite remaining within the normal range was associated with a twofold increased risk of nonrelapse mortality. Neither airflow obstruction nor impairment in diffusing capacity was associated with an increased risk. Abnormalities of the TLC at 3 mo after transplant were associated with death with respiratory failure, but not with an increased risk of chronic graft-versus-host disease (GVHD). There is an increase in the nonrelapse mortality rate associated with either the presence of a restrictive defect 3 mo after marrow transplantation or a significant decline in lung volume compared with baseline. This effect is most pronounced more than 1 yr after marrow transplant and appears to be a result of an increase in the rate of death with respiratory failure, not chronic GVHD.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1164\/ajrccm.152.2.7633727","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:10Z","timestamp":1365097990000},"page":"690-695","source":"Crossref","is-referenced-by-count":40,"title":["Abnormalities of Pulmonary Function Tests After Marrow Transplantation Predict Nonrelapse Mortality"],"prefix":"10.1093","volume":"152","author":[{"given":"S W","family":"Crawford","sequence":"first","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pepe","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Deeg","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,8,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/2\/690\/67626928\/ajrccm_152_2_690.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/2\/690\/67626928\/ajrccm_152_2_690.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:43:12Z","timestamp":1774687392000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/152\/2\/690\/8553788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1995,8,1]]},"published-print":{"date-parts":[[1995,8,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.152.2.7633727","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,8]]},"published":{"date-parts":[[1995,8,1]]}}}