{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:47:57Z","timestamp":1774691277755,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have assessed the diagnostic value of site-directed bronchoalveolar lavage (BAL) and combined transbronchial biopsy (TBB) in 29 HIV-infected patients with localized pneumonia, in whom a previous BAL was nondiagnostic and in whom improvement did not occur with empiric antibiotic therapy. All patients but three had a CD4 cell count &amp;lt; 100\/microliters. A definite diagnosis could be reached in 26 of 29 (90%) individuals, including 24 pathogens. Neither the radiologic pattern nor the type of Pneumocystis carinii (PC) prophylaxis could predict the positivity of either one of these two diagnostic procedures. Site-directed BAL alone allowed a diagnosis in infection in eight (28%) cases. TBB alone led to diagnosis in eight (28%) cases, including three PC and two toxoplasma gondii, undiagnosed by the site-directed BAL. Both techniques were positive and in agreement in 10 (34%) cases. The majority of the diagnosis led to a specific treatment. Therefore, the patients' survival was positively altered by the procedure. In conclusion, the performance of site-directed BAL and combined TBB markedly optimizes the diagnostic yield of each of these procedures performed separately in HIV-infected patients with localized pneumonia.<\/jats:p>","DOI":"10.1164\/ajrccm.152.3.7663791","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:27Z","timestamp":1365098007000},"page":"1103-1106","source":"Crossref","is-referenced-by-count":25,"title":["Site-Directed Bronchoalveolar Lavage and Transbronchial Biopsy in HIV-Infected Patients With Pneumonia"],"prefix":"10.1093","volume":"152","author":[{"given":"J","family":"Cadranel","sequence":"first","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Gillet-Juvin","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Antoine","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Carnot","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Reynaud","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Parrot","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Carette","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mayaud","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Isra\u00ebl-Biet","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,9,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/3\/1103\/67627338\/ajrccm_152_3_1103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/3\/1103\/67627338\/ajrccm_152_3_1103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:47:52Z","timestamp":1774687672000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/152\/3\/1103\/8553851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1995,9,1]]},"published-print":{"date-parts":[[1995,9,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.152.3.7663791","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,9]]},"published":{"date-parts":[[1995,9,1]]}}}