{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:09:13Z","timestamp":1774688953514,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1995,11,1]],"date-time":"1995-11-01T00:00:00Z","timestamp":815184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polymorphonuclear leukocytes (PMN) are the predominant inflammatory cells recruited in acute lung injury. This study compares the concentration of interleukin-8 (IL-8) to those of GRO alpha, both of which are CXC chemokines, in bronchoalveolar lavage fluid (BALF) in three acute pathologic states: bacterial pneumonia (BPN); adult respiratory distress syndrome (ARDS); and Pneumocystis carinii pneumonia (PCP). Levels of both IL-8 and GRO alpha were below 5 pg\/ml in 16 nonsmoking volunteers who served as controls. Despite more than twice as many neutrophils in the BALF of the BPN group (n = 12) than in the group with ARDS (n = 13), both groups had similar levels of IL-8, of 569 +\/- 120 pg\/ml and 507 +\/- 96 pg\/ml, respectively. The GRO alpha concentrations in the BPN and ARDS patients were respectively 3.3 and 3.4 times those of IL-8, reaching 1,870 +\/- 314 pg\/ml for the BPN and 1,699 +\/- 377 for the ARDS patients. In the PCP group (n = 48, 45 human immunodeficiency virus [HIV]-positive, 3 HIV-negative), GRO alpha levels (897 +\/- 172 pg\/ml) were sevenfold higher than IL-8 levels (123 +\/- 40 pg\/ml). In all pathologic states there was a good correlation between GRO alpha and IL-8 (r = 0.53, p = 0.0001). GRO alpha or IL-8 both correlate with the absolute neutrophil number\/ml when all groups were studied together (r = 0.52, p = 0.0001). Only in the PCP and ARDS groups did IL-8 correlate with the PMN number.(ABSTRACT TRUNCATED AT 250 WORDS)<\/jats:p>","DOI":"10.1164\/ajrccm.152.5.7582292","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:26Z","timestamp":1365098006000},"page":"1549-1554","source":"Crossref","is-referenced-by-count":69,"title":["GRO Alpha and Interleukin-8 in Pneumocystis Carinii or Bacterial Pneumonia and Adult Respiratory Distress Syndrome"],"prefix":"10.1093","volume":"152","author":[{"given":"J","family":"Villard","sequence":"first","affiliation":[{"name":"Department of Medicine, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Dayer-Pastore","sequence":"additional","affiliation":[{"name":"Department of Medicine, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hamacher","sequence":"additional","affiliation":[{"name":"Department of Medicine, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Aubert","sequence":"additional","affiliation":[{"name":"Department of Medicine, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Schlegel-Haueter","sequence":"additional","affiliation":[{"name":"Department of Medicine, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L P","family":"Nicod","sequence":"additional","affiliation":[{"name":"Department of Medicine, H\u00f4pital Cantonal Universitaire, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1995,11,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/5\/1549\/67627467\/ajrccm_152_5_1549.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/5\/1549\/67627467\/ajrccm_152_5_1549.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:47:39Z","timestamp":1774687659000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/152\/5\/1549\/8553902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1995,11,1]]},"published-print":{"date-parts":[[1995,11,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.152.5.7582292","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,11]]},"published":{"date-parts":[[1995,11,1]]}}}