{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:38:15Z","timestamp":1790937495323,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To determine the usefulness of positron emission tomography with fluoro-2-deoxyglucose (PET-FDG) in assessing mediastinal disease in patients with non-small-cell lung cancer (NSCLC) and to compare its yield to that of computed tomography (CT), we performed a prospective consecutive sample investigation in a university hospital and its related clinics. In 30 patients with NSCLC with clinical stage I (T1-2, NO, MO) disease, we compared the results of chest CT and PET-FDG with the findings at surgical exploration of the mediastinum. Seven (77%) of nine patients with surgically proven mediastinal metastasis were identified by the PET-FDG results, with four false-positives in 21 patients with negative lymph node dissections (p = 0.004). Using the results of pathologic examination of mediastinal lymph nodes as the criterion standard, the diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for PET-FDG imaging of mediastinal metastases were 78%, 81%, 80%, 64%, and 89%, respectively. The sensitivity, specificity, accuracy, PPV, and NPV for chest CT in the detection of mediastinal metastasis were 56%, 86%, 77%, 63%, and 87%, respectively. CT and PET-FDG results agreed in 21 patients. The diagnostic accuracy of the combined imaging modalities was 90%. We concluded that mediastinal uptake of FDG correlates with the extent of mediastinal involvement of NSCLC and may contribute to preoperative staging. PET-FDG imaging complements chest CT in the noninvasive evaluation of NSCLC, and strategies for its use merit further investigation.<\/jats:p>","DOI":"10.1164\/ajrccm.152.6.8520780","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:31Z","timestamp":1365098011000},"page":"2090-2096","source":"Crossref","is-referenced-by-count":120,"title":["Mediastinal Staging of Non-Small-Cell Lung Cancer With Positron Emission Tomography"],"prefix":"10.1093","volume":"152","author":[{"suffix":"Jr","given":"R","family":"Chin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Keyes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"Choplin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Wallenhaupt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S","family":"Hudspeth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E F","family":"Haponik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1995,12,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/6\/2090\/67629725\/ajrccm_152_6_2090.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/152\/6\/2090\/67629725\/ajrccm_152_6_2090.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:44:09Z","timestamp":1774694649000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/152\/6\/2090\/8554036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1995,12,1]]},"published-print":{"date-parts":[[1995,12,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.152.6.8520780","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1995,12]]},"published":{"date-parts":[[1995,12,1]]}}}