{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:08:10Z","timestamp":1791083290600,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Historically, infections caused by Mycobacterium tuberculosis have been treated simultaneously with isoniazid and rifampin. As a consequence of this combined therapy, strains resistant only to rifampin were rarely recovered. However, recently there has been an increasing number of reports describing HIV-positive patients infected with mono-rifampin-resistant M. tuberculosis strains. Organisms cultured from seven patients (including six with AIDS) with infections caused by mono-rifampin-resistant M. tuberculosis, and seen at one New York City hospital, were analyzed by molecular techniques to test the hypothesis that dissemination of a single clone had occurred. IS6110 DNA fingerprinting and automated DNA sequencing of a region of the RNA polymerase beta subunit structural gene (rpoB) containing mutations that confer rifampin resistance showed that all organisms independently acquired the mono-rifampin-resistant phenotype. Molecular analysis of mono-rifampin-resistant organisms cultured from 13 additional patients in New York City confirmed independent strain origin. The data rule out the possibility of person-to-person strain transmission among these patients, and they suggest that host factors such as poor compliance with antituberculosis medications or decreased absorption of rifampin have been a driving force in the origin of these strains.<\/jats:p>","DOI":"10.1164\/ajrccm.153.2.8564140","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:58Z","timestamp":1365098038000},"page":"837-840","source":"Crossref","is-referenced-by-count":52,"title":["Independent Origin of Mono-Rifampin-Resistant Mycobacterium Tuberculosis in Patients With AIDS"],"prefix":"10.1093","volume":"153","author":[{"given":"M","family":"Lutfey","sequence":"first","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Della-Latta","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Kapur","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Palumbo","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gurner","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Stotzky","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Brudney","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Dobkin","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moss","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Musser","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B N","family":"Kreiswirth","sequence":"additional","affiliation":[{"name":"Tuberculosis Center, Public Health Research Institute, Columbia Presbyterian Medical Center, New York, New York 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,2,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/153\/2\/837\/67616755\/ajrccm_153_2_837.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/153\/2\/837\/67616755\/ajrccm_153_2_837.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:17:07Z","timestamp":1774682227000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/153\/2\/837\/8552783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1996,2,1]]},"published-print":{"date-parts":[[1996,2,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.153.2.8564140","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,2]]},"published":{"date-parts":[[1996,2,1]]}}}