{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:23:06Z","timestamp":1774682586662,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In order to test the hypothesis that ozone (O3)-induced changes in lung function and respiratory tract injury\/inflammation are greater in subjects with asthma than in normal subjects, we exposed 18 asthmatic subjects, on separate days, to O3 (0.2 ppm) and filtered air for 4 h during exercise. Symptom questionnaires were administered before and after exposure, and pulmonary function tests (FEV1, FVC, and specific airway resistance [SRaw]) were performed before, during, and immediately after each exposure. Fiberoptic bronchoscopy, with proximal airway lavage (PAL) of the isolated left main bronchus and bronchoalveolar lavage (BAL; bronchial fraction, the first 10 ml of fluid recovered) of the right middle lobe, was performed 18 h after each exposure. The PAL, bronchial fraction, and BAL fluids were analyzed for the following endpoints: total and differential cell counts; total protein, lactate dehydrogenase (LDH), fibronectin, interleukin-8 (IL-8), granulocyte-macrophage colony-stimulating factor (GM-CSF), myeloperoxidase (MPO), and transforming growth factor-beta (TGF beta 2) concentrations. We found a significant O3 effect on FEV1, FVC, SRaw (p &amp;lt; 0.04) and lower respiratory symptoms (p &amp;lt; 0.001) for the asthmatic subjects. Ozone exposure also significantly increased the percent neutrophils in PAL (p &amp;lt; 0.01); percent neutrophils, total protein, and IL-8 in the bronchial fraction (p &amp;lt; 0.001, p &amp;lt; 0.05, and p &amp;lt; 0.01, respectively); and the percent neutrophils, total protein, LDH, fibronectin, IL-8, GM-CSF, and MPO in BAL (p &amp;lt; 0.001, p &amp;lt; 0.01, p &amp;lt; 0.01, p &amp;lt; 0.001, p &amp;lt; 0.05, p &amp;lt; 0.01, and p &amp;lt; 0.001, respectively) for the asthmatic subjects. There were no significant differences in the lung function responses of the asthmatic subjects in comparison with a group of normal subjects (n = 81) previously studied using an identical protocol, although there was a trend toward a greater O3-induced increase in SRaw in the asthmatic subjects (p &amp;lt; 0.13). In contrast, the asthmatic subjects showed significantly greater (p &amp;lt; 0.05) O3-induced increases in several inflammatory endpoints (percent neutrophils and total protein concentration) in BAL as compared with normal subjects who underwent bronchoscopy (n = 20). Our results indicate that asthmatic persons may be at risk of developing more severe O3-induced respiratory tract injury\/inflammation than normal persons, and may help explain the increased asthma morbidity associated with O3 pollution episodes observed in epidemiologic studies.<\/jats:p>","DOI":"10.1164\/ajrccm.154.1.8680687","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:54:01Z","timestamp":1365098041000},"page":"24-29","source":"Crossref","is-referenced-by-count":125,"title":["Greater Ozone-Induced Inflammatory Responses in Subjects With Asthma"],"prefix":"10.1093","volume":"154","author":[{"given":"C","family":"Scannell","sequence":"first","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Chen","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Aris","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Tager","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Christian","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ferrando","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Welch","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kelly","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Balmes","sequence":"additional","affiliation":[{"name":"Lung Biology Center, San Francisco General Hospital, University of California 94143-0854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,7,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/1\/24\/67614238\/ajrccm_154_1_24.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/1\/24\/67614238\/ajrccm_154_1_24.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:34:51Z","timestamp":1774679691000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/154\/1\/24\/8552568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1996,7,1]]},"published-print":{"date-parts":[[1996,7,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.154.1.8680687","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,7]]},"published":{"date-parts":[[1996,7,1]]}}}