{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:49:15Z","timestamp":1774684155892,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acid-aspiration-induced injury is one of the leading causes of adult respiratory distress syndrome. Intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte-function-associated antigen-1 alpha (LFA-1 alpha), and it has been shown to be required for leukocyte migration into inflamed areas. The purpose of this report was to investigate the role of the ICAM-1\/LFA-1 alpha pathway in a rat model of acid-aspiration-induced injury. Animals received 3.0 ml\/kg HCI (0.1N; pH, 1.0) intratracheally pretreated with control monoclonal antibodies (mAbs) (HCI group) or anti-ICAM-1 and LFA-1 alpha mAbs (Test group). In the HCI group, increases in lung resistance (RL) (229 +\/- 23% baseline), lung wet-to-dry weight ratio (W\/D) (11.9 +\/- 0.4), protein concentration (TP) (0.447 +\/- 0.054 mg\/ml), and the number of neutrophils (PMN) (159.0 +\/- 19.4 x 10(4)) of bronchoalveolar lavage fluid were observed. In the Test group, HCI-induced injury was significantly reduced (RL, 122 +\/- 7% baseline; W\/D, 7.2 +\/- 0.1; TP, 0.277 +\/- 0.016 mg\/ml; PMN, 8.8 +\/- 0.8 x 10(4)). The administration of mAbs to ICAM-1 and LFA-1 alpha after HCI instillation partially attenuated HCI-induced responses. These observations suggest that the ICAM-1\/LFA-1 alpha pathway might be involved in the pathogenesis of adult respiratory distress syndrome caused by acid aspiration.<\/jats:p>","DOI":"10.1164\/ajrccm.154.2.8756829","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:53:52Z","timestamp":1365098032000},"page":"504-510","source":"Crossref","is-referenced-by-count":41,"title":["Intercellular Adhesion Molecule-1 Mediates Acid Aspiration-Induced Lung Injury"],"prefix":"10.1093","volume":"154","author":[{"given":"T","family":"Nagase","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ohga","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Uejima","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Matsuse","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,8,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/2\/504\/67615000\/ajrccm_154_2_504.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/2\/504\/67615000\/ajrccm_154_2_504.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:55:10Z","timestamp":1774680910000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/154\/2\/504\/8552608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1996,8,1]]},"published-print":{"date-parts":[[1996,8,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.154.2.8756829","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,8]]},"published":{"date-parts":[[1996,8,1]]}}}