{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:49:05Z","timestamp":1787161745089,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stimulation of the airways of asthmatic individuals causes severe bronchoconstriction, which is in part neurally mediated via the vagus nerve. Local anesthetics are commonly administered to prevent this reflex-induced bronchoconstriction. Therefore, in a double-blind, placebo-controlled prospective study, we tested the effectiveness of oral mexiletine and intravenous lidocaine at blocking histamine-induced reflex bronchoconstriction. Fifteen subjects with mild asthma were selected (for whom the provocative concentration of histamine aerosol causing a 20% decrease in FEV1 (PC20) was less than 18 mg\/ml). Subsequently, the subjects were pretreated with oral mexiletine, intravenous lidocaine, or placebo, and the histamine challenges were repeated. The baseline PC20 for histamine was 8.8 +\/- 1.8 mg\/ml. Mexiletine and lidocaine at therapeutic serum concentrations blocked reflex bronchoconstriction. Oral mexiletine increased the PC20 to 21.1 +\/- 5.0 mg\/ml (serum concentration: 0.7 +\/- 0.05 microg\/ml). Likewise, intravenous lidocaine increased the PC20 to 24.5 +\/- 4.9 mg\/ml (serum concentration: 2.6 +\/- 0.15 microg\/ml). Oral mexiletine and intravenous lidocaine block reflex-induced bronchoconstriction. Furthermore, mexiletine may have additional airway benefits when selected for the treatment of dysrhythmias or chronic pain in patients with coexisting lung diseases.<\/jats:p>","DOI":"10.1164\/ajrccm.154.4.8887580","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:54:18Z","timestamp":1365098058000},"page":"885-888","source":"Crossref","is-referenced-by-count":27,"title":["Intravenous Lidocaine and Oral Mexiletine Block Reflex Bronchoconstriction in Asthmatic Subjects"],"prefix":"10.1093","volume":"154","author":[{"given":"H","family":"Groeben","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Environmental Health Services, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Environmental Health Services, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Environmental Health Services, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1996,10,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/4\/885\/67612761\/ajrccm_154_4_885.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/4\/885\/67612761\/ajrccm_154_4_885.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:49:30Z","timestamp":1774676970000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/154\/4\/885\/8552340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1996,10,1]]},"published-print":{"date-parts":[[1996,10,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.154.4.8887580","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,10]]},"published":{"date-parts":[[1996,10,1]]}}}