{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:04:41Z","timestamp":1774681481129,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been reported that hyperpnea-induced bronchoconstriction in guinea pigs is a potential model for exercise-induced asthma in humans. We hypothesized that calcitonin gene-related peptide (CGRP) could modulate leukotriene D4 (LTD4)-induced responses and be involved in the pathophysiology in this asthma model. We measured tracheal (Ptr) and alveolar pressure (PA) using alveolar capsules in open-chested, mechanically ventilated (f = 1 Hz, VT = 9 ml\/kg, PEEP = 4 cm H2O) guinea pigs. Animals were intravenously pretreated with saline (SAL), CGRP(8-37) (CGRP receptor antagonist), CGRP, MK-571 (LTD4 receptor antagonist), MK-886 (5-lipoxygenase inhibitor), or CGRP(8-37) + MK-571, and then underwent dry gas hyperpnea challenge (HC, 95% 02-5% CO2, 150 breaths\/min, 7 min). We calculated resistance of lung (RL), tissue (Rti), and airway (Raw). HC increased RL, Rti, and Raw in SAL controls (322 +\/- 27, 430 +\/- 59, 299 +\/- 23% baseline, respectively). MK-571, MK-886, and CGRP significantly reduced the responses to HC, while CGRP(8-37) enhanced HC-induced responses. Pretreatment with CGRP(8-37) and MK-571 in combination attenuated HC-induced constriction. In addition, pretreatment with CGRP reduced responses induced by intravenous administration of LTD4. These observations suggest that CGRP might be involved in the pathophysiology of hyperpnea-induced constriction in guinea pigs via modulation of LTD4-elicited responses.<\/jats:p>","DOI":"10.1164\/ajrccm.154.5.8912779","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T17:54:44Z","timestamp":1365098084000},"page":"1551-1556","source":"Crossref","is-referenced-by-count":11,"title":["Roles of Calcitonin Gene-Related Peptide (CGRP) in Hyperpnea-Induced Constriction in Guinea Pigs"],"prefix":"10.1093","volume":"154","author":[{"given":"T","family":"Nagase","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ohga","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Matsuse","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1996,11,1]]},"container-title":["American journal of respiratory and critical care medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/5\/1551\/67612329\/ajrccm_154_5_1551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajrccm\/article-pdf\/154\/5\/1551\/67612329\/ajrccm_154_5_1551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:48:49Z","timestamp":1774676929000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajrccm\/article\/154\/5\/1551\/8552266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1996,11,1]]},"published-print":{"date-parts":[[1996,11,1]]}},"URL":"https:\/\/doi.org\/10.1164\/ajrccm.154.5.8912779","relation":{},"ISSN":["1073-449X","1535-4970"],"issn-type":[{"value":"1073-449X","type":"print"},{"value":"1535-4970","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1996,11]]},"published":{"date-parts":[[1996,11,1]]}}}